Purpura fulminans yog ib qho kab mob sib kis uas sawv cev rau daim ntawv mob hnyav heev. Nws ua rau cov ntshav txhaws thiab cov ntaub so ntswg necrosis. Nws feem ntau tshwm sim los ntawm tus kab mob meningococcal invasive thiab nws cov txiaj ntsig yuav tuag yog tias tsis tau saib xyuas lub sijhawm.

Ua npaws siab, ua tsis taus pa loj heev, ntuav thiab mob plab yog thawj cov tsos mob tsis zoo. Ib lossis ntau qhov liab thiab ntshav liab kis tau sai rau ntawm daim tawv nqaij, feem ntau ntawm cov ceg qis. Qhov no yog purpura, los ntshav ntawm daim tawv nqaij. Lub siab ntawm daim tawv nqaij tsis tso cov ntshav thiab tsis ua rau cov stain ploj mus ib ntus, ib qho cim ntawm "extravasation" ntawm cov ntshav hauv cov ntaub so ntswg. Qhov no yog vim Purpura Fulminans ua rau nthuav tawm intravascular coagulation (DIC), uas yog tsim los ntawm cov hlab ntsha me me uas yuav cuam tshuam cov ntshav ntws (thrombosis), coj nws mus rau dermis thiab ua rau hemorrhage thiab necrosis ntawm daim tawv nqaij. Cov kab mob kis tau tuaj yeem nrog lub xeev ntawm kev poob siab lossis kev cuam tshuam ntawm kev nco qab ntawm tus neeg mob.

Nyob rau hauv feem ntau ntawm cov mob, purpura fulminans yog txuas mus rau ib tug invasive kab mob thiab hnyav kab mob. Neisseria meningitidis (meningococcus) yog tus kab mob kis tau zoo tshaj plaws, suav txog kwv yees li 75% ntawm cov neeg mob. Qhov kev pheej hmoo ntawm kev tsim purpura fulminans tshwm sim hauv 30% ntawm cov kab mob meningococcal invasive (IIMs). (2) 1 txog 2 tus neeg mob ntawm IMD rau 100 tus neeg nyob hauv txhua xyoo nyob rau Fabkis, nrog rau cov neeg mob tuag ntawm ib ncig ntawm 000%. (10)

Lwm cov kab mob tuaj yeem ua lub luag haujlwm rau kev txhim kho purpura fulminans, xws li Streptococcus pneumoniae (pneumococcus) los yog Haemophilus influenzae (Pfeiffer's bacillus). Qee lub sij hawm qhov ua rau yog qhov tsis txaus ntawm cov protein C lossis S, uas ua lub luag haujlwm hauv coagulation, vim yog qhov tshwm sim ntawm caj ces txawv txav: kev hloov pauv ntawm PROS1 noob (3q11-q11.2) rau cov protein C thiab PROC gene (2q13-q14) rau cov protein C. Nws yuav tsum tau muab sau tseg tias purpura fulgurans tuaj yeem tshwm sim los ntawm tus kab mob me me xws li kab mob qhua pias, hauv qhov tsis tshua muaj neeg.

Purpura fulminans tuaj yeem cuam tshuam rau txhua lub hnub nyoog, tab sis cov menyuam mos hnub nyoog qis dua 15 xyoos thiab cov tub ntxhais hluas hnub nyoog 20 txog 1 xyoos muaj kev pheej hmoo ntau dua. (XNUMX) Cov neeg uas tau nyob ze nrog cov neeg raug tsim txom ntawm septic shock yuav tsum tau txais kev kho mob tiv thaiv kom tsis txhob muaj kev pheej hmoo kis mob.

Qhov kev kwv yees tau txuas ncaj qha mus rau lub sijhawm ua haujlwm. Purpura fulminans tiag tiag sawv cev rau qhov xwm txheej ntawm qhov xwm txheej ceev heev uas yuav tsum tau kho cov tshuaj tua kab mob kom ntxov li sai tau, tsis tas tos qhov kev pom zoo ntawm kev kuaj mob thiab tsis raug rau cov txiaj ntsig ua ntej ntawm cov kab lis kev cai lossis kev kuaj ntshav. Ib qho purpura uas muaj tsawg kawg yog ib qho chaw uas muaj txoj kab uas hla ntau dua lossis sib npaug li 3 millimeters, yuav tsum tau ua kom muaj kev ceeb toom thiab kho tam sim ntawd. Kev kho tshuaj tua kab mob yuav tsum tsim nyog rau cov kab mob meningococcal thiab ua rau hauv cov hlab ntsha lossis, ua tsis tiav, intramuscularly.