Cov ntsiav tshuaj yog txoj hauv kev tseem ceeb ntawm kev tiv thaiv kab mob rau cov poj niam Fabkis. Combined oral contraceptives (COCs) hu ua estrogen-progestogen pills los yog cov tshuaj ua ke yog cov feem ntau siv. Lawv muaj ob qho tib si estrogen thiab progestin. Feem ntau siv tshuaj estrogen yog ethinyl estradiol (ib qho derivative ntawm estradiol). Nws yog hom progestin uas txiav txim siab tiam ntawm cov tshuaj. 66 lab platelets ntawm cov tshuaj tiv thaiv kab mob sib xyaw ua ke (COC), txhua tiam neeg ua ke, tau muag hauv Fab Kis xyoo 2011. Nco ntsoov: tag nrho cov tshuaj tiam thib ob raug them rov qab rau xyoo 2, thaum tsawg dua ib nrab ntawm cov tiam thib 2012 thiab tsis muaj 3 tiam tsis tau them los ntawm Kev pov hwm kho mob.
1st tiam ntsiav tshuaj
Cov tshuaj 1st tiam, ua lag luam hauv 60s, muaj cov tshuaj estrogen ntau. Cov tshuaj no yog nyob rau hauv keeb kwm ntawm ntau yam kev phiv: o ntawm lub mis, xeev siab, migraines, vascular mob. Tsuas yog ib ntsiav tshuaj ntawm hom no tau muag hnub no hauv Fabkis.. Qhov no yog Triella.
2nd tiam tshuaj
Lawv tau ua lag luam txij li xyoo 1973. Cov tshuaj no muaj levonorgestrel lossis norgestrel ua progestogen. Kev siv cov tshuaj hormones no ua rau nws muaj peev xwm txo qis qib ntawm ethinyl estradiol thiab yog li txo cov kev mob tshwm sim ntawm cov poj niam yws yws. Yuav luag ib ntawm ob tus poj niam noj tshuaj 2nd tiam ntawm cov neeg siv cov tshuaj tiv thaiv qhov ncauj ua ke (COCs).
3rd thiab 4th tiam tshuaj
Cov tshuaj tshiab tau tshwm sim hauv xyoo 1984. Cov tshuaj tiv thaiv thib 3 muaj ntau hom progestins: desogestrel, gestodene lossis norgestimate. Qhov peculiarity ntawm cov tshuaj no yog tias lawv muaj qis dua ntawm estradiol, yog li txhawm rau txhawm rau txo qhov tsis yooj yim, xws li pob txuv, qhov hnyav nce, cov roj cholesterol. Tsis tas li ntawd, cov kws tshawb fawb tau pom tias ntau dhau ntawm cov tshuaj hormone no tuaj yeem txhawb qhov tshwm sim ntawm venous thrombosis. Xyoo 2001, 4th tiam tshuaj tau qhia rau lub khw. Lawv muaj cov progestins tshiab (drospirenone, chlormadinone, dienogest, nomégestrol). Cov kev tshawb fawb tsis ntev los no tau pom tias cov tshuaj tiam thib 3 thiab 4 muaj ob zaug qhov kev pheej hmoo ntawm thromboembolism piv rau cov tshuaj tiam thib 2.. Lub sijhawm no, nws yog cov progestins uas tau nug. Txog niaj hnub no, 14 qhov kev tsis txaus siab tau raug foob rau lub chaw soj nstuam tsim tshuaj tiv thaiv kab mob thib 3 thiab thib 4. Txij li xyoo 2013, cov tshuaj tiv thaiv kab mob thib 3 tsis tau them rov qab lawm.
Diane Case 35 Lub Chaw Haujlwm Saib Xyuas Kev Nyab Xeeb Hauv Lub Tebchaws rau Kev Nyab Xeeb Kev Noj Qab Haus Huv (ANSM) tau tshaj tawm qhov kev ncua ntawm kev tso cai ua lag luam (AMM) rau Diane 35 thiab nws cov khoom lag luam. Qhov kev kho mob pob txuv hormonal no tau raug sau tseg raws li kev tiv thaiv kab mob. Plaub qhov kev tuag "ua tau los ntawm venous thrombosis" yog txuas nrog Diane 35. " |
Source: Medicines Agency (ANSM)