Kuj tseem hu ua fetuin,alpha-fetoprotein yog ib tug protein ntuj tsim los ntawm nkaub qe thiab nplooj siab du fetus hauv kev txhim kho Nws pom nyob hauv cov menyuam hauv plab thiab niam cov ntshav (thaum cev xeeb tub). Hauv cov menyuam yug tshiab, nws tus nqi txo qis ob peb lub lis piam tom qab yug los.

Hauv cov neeg laus, alpha-fetoprotein tuaj yeem rov tshwm sim thaum muaj qee yam kab mob, feem ntau yog lub siab lossis qog.

Kev tshuaj xyuas Alpha-fetoprotein tuaj yeem muab rau tus poj niam thaum cev xeeb tub lossis rau cov neeg laus sab nraud ntawm cev xeeb tub.

Thaum lub sij hawm cev xeeb tub, kev tshuaj ntsuam alpha-fetoprotein yog siv rau kev kuaj mob ua ntej yug menyuam ntawm ntau yam txawv txav thiab tau ua tiav nyob rau lub hlis thib ob. Qhov kev xeem no feem ntau yog qhov tseeb ntawm lub lis piam 16 thiab 18. Kev tshuaj xyuas alpha-fetoprotein tshwm sim ua ke nrog tib neeg chorionic gonadotropic hormone (HCG), estriol thiab inhibin A, cov tshuaj placental. Lub hom phiaj tshwj xeeb yog txhawm rau txheeb xyuas qhov ua tsis zoo ntawm cov hlab ntsha neural (uas yuav dhau los ua lub cev tsis muaj zog) ntawm tus menyuam hauv plab, xws li Spina bifida, tab sis kuj tseem muaj cov chromosomal txawv txav, xws li kev pheej hmoo ntawm trisomy 21 (lossis Down's syndrome).

Hauv cov neeg laus (sab nraum cev xeeb tub), kev tshuaj xyuas alpha-fetoprotein tuaj yeem kuaj xyuas teeb meem daim siab lossis kuaj qee yam qog nqaij hlav.

Kev tshuaj xyuas ntawm alpha-fetoprotein suav nrog a kuaj ntshav nyob rau theem ntawm cov leeg thiab tsis xav tau kev npaj tshwj xeeb. Tus kws kho mob muab lub raj tso rau ntawm tus neeg mob lub caj npab pem hauv ntej, txog 10 cm siab dua ntawm qhov chaw uas yuav siv tshuaj tiv thaiv kab mob, feem ntau yog nyob ntawm lub luj tshib.

Hauv cov poj niam cev xeeb tub, ib feem ntawm alpha-fetoprotein tsim los ntawm tus me nyuam hauv plab nkag mus rau hauv niam cov ntshav, thiab yog li ntawd tsis tas yuav siv amniotic lossis fetal sampling. Cov qauv ntshav tau muab coj los ua "classic".

Hauv cov neeg laus, txiv neej thiab poj niam sab nraum lub sijhawm cev xeeb tub, qhov ib txwm muaj ntawm alpha-fetoprotein tsawg dua 10 ng / ml ntawm cov ntshav.

Kev nce qib ntawm alpha-fetoprotein hauv cov ntshav tuaj yeem nthuav tawm:

• kab mob siab, xws li mob ntsws, rau ib qho mob siab mob cancer, lub dej cawv kab mob siab los yog mus rau kis mob siab

• un cancer noob qes, zes qe menyuam, plab, txiav txiav lossis cov kua tsib ducts.

Hauv cov poj niam cev xeeb tub, nyob rau lub hlis thib ob, qib alpha-fetoprotein feem ntau yog nruab nrab ntawm 10 thiab 200 ng / ml. Kev nce qib alpha-fetoprotein tuaj yeem ua rau:

• neural tube tsis xws luag hauv tus menyuam hauv plab: Spina bifida, anencephaly

• neurological malformation

• hydroencephaly

• qhov ua tsis zoo ntawm txoj hlab pas lossis lub raum

Hloov pauv, qib qis tuaj yeem yog ib qho cim ntawm chromosomal txawv txav xws li Down syndrome (trisomy 21).

Ceev faj, txawm li cas los xij, qib alpha-fetoprotein sib txawv thaum cev xeeb tub. Yog li ntawd nws yog ib qho tseem ceeb kom paub meej txog theem ntawm cev xeeb tub uas tus poj niam tab tom xeem. Cov txiaj ntsig tsis zoo alpha-fetoprotein kuj tseem yuav yog vim muaj menyuam ntau lossis cev xeeb tub tuag.

Yog li kev tshuaj xyuas ntxiv yog qhov tsim nyog thaum muaj qhov txawv txav alpha-fetoprotein qib, xws li ultrasound lossis amniocentesis (tshem tawm cov kua amniotic ib puag ncig tus menyuam hauv plab).