txheem
Nyob rau hauv txoj kab nrog nws lub luag haujlwm, Pawg Thawj Saib Xyuas Haujlwm ntawm MedTvoiLokony ua txhua yam los muab cov ntsiab lus kho mob txhim khu kev qha txhawb nqa los ntawm kev paub txog kev tshawb fawb tshiab. Tus chij ntxiv "Cov Ntsiab Lus Tshawb Fawb" qhia tias tsab xov xwm tau raug tshuaj xyuas los ntawm lossis sau ncaj qha los ntawm tus kws kho mob. Qhov kev pov thawj ob kauj ruam no: tus kws sau ntawv kho mob thiab kws kho mob tso cai rau peb muab cov ntsiab lus zoo tshaj plaws raws li kev paub txog kev kho mob tam sim no.
Peb txoj kev mob siab rau hauv cheeb tsam no tau txais txiaj ntsig zoo, thiab lwm yam, los ntawm Lub Koom Haum ntawm Cov Neeg Sau Xov Xwm rau Kev Noj Qab Haus Huv, uas tau muab khoom plig rau Pawg Thawj Coj ntawm MedTvoiLokony nrog lub npe qhuas ntawm Tus Kws Qhia Ntawv Zoo.
Alzheimer's disease yog kab mob neurodegenerative uas feem ntau cuam tshuam rau cov neeg laus. Cov tsos mob muaj xws li mob dementia, teeb meem nco, chim siab thiab mus ob peb vas. Alzheimer's disease yog kho tsis tau thiab feem ntau tsis suav nrog cov neeg mob los ntawm kev ua haujlwm ywj pheej.
Ua rau Alzheimer's disease
Qhov tshwm sim ntawm Alzheimer's kab mob yog txuam nrog ntau yam: noob caj noob ces, ib puag ncig, thiab kev puas siab puas ntsws (ntev kev puas siab puas ntsws ncua tus kab mob). Txog tam sim no, txawm li cas los xij, kev txiav txim siab ua rau Alzheimer's tus kab mob tseem tsis tau tsim. Muaj ntau qhov kev xav txog kev tshawb fawb, suav nrog kev hloov pauv hauv DNA uas tuaj yeem ua rau pom tus kab mob.
Alzheimer's kab mob ua rau, inter alia, kev paub tsis meej uas tshwm sim los ntawm kev cuam tshuam hauv cov teeb liab hloov hauv cholinergic system ntawm lub forebrain. Cov kab mob no tshwm sim los ntawm degeneration ntawm cholinergic neurons (lub luag hauj lwm rau kev mloog, ceeb toom). Lwm cov neurons kuj raug puas ntsoog, uas ua rau apathy, delusions, aggression, thiab coj cwj pwm phem.
Cov chav kawm ntawm Alzheimer's disease
Lub ntsiab ua rau dementia hauv Alzheimer's kab mob yog kev puas tsuaj rau cholinergic neurons, txawm li cas los xij, qhov ntxov tshaj plaws amyloid deposits tshwm nyob rau hauv glutamatergic neurons lub luag hauj lwm rau excitatory kis ntawm lub hlwb, nyob rau hauv lub entorhinal thiab associative cortex thiab lub hippocampus. Cov qauv ntawm lub hlwb no yog lub luag haujlwm rau kev nco thiab kev nkag siab. Tom qab ntawd cov plaques tshwm sim hauv cholinergic thiab serotonin fibers. Raws li tus kab mob loj hlob zuj zus, tus nqi ntawm amyloid deposits nce thiab ua rau lub extinction ntawm glutamatergic, cholinergic, serotonin thiab noradrenergic neurons.
Alzheimer's tus kab mob pib imperceptibly thiab tsis muaj ib tug standardized chav kawm. Nws kav li ntawm 5 mus rau 12 xyoo. Thawj cov tsos mob yog kev nco thiab mus ob peb vas (kev nyuaj siab thiab hais lus-lub cev aggression). Tom qab ntawd, cov teeb meem nrog lub cim xeeb tshiab thiab nyob deb zuj zus, ua rau nws tsis tuaj yeem ua haujlwm ntawm nws tus kheej. Cov neeg mob Alzheimer pib muaj teeb meem hais lus, tshuaj noj thiab kev xav tsis zoo. Hauv cov kab mob siab heev, tus neeg mob tsis tuaj yeem paub leej twg, hais ib lo lus, qee zaum tsis hais txhua. Feem ntau, nws siv sijhawm tag nrho hauv txaj thiab tsis tuaj yeem noj ntawm nws tus kheej. Feem ntau nws dhau los ua apathetic heev, tab sis qee zaum muaj cov tsos mob ntawm kev kub ntxhov.
Kev kho mob Alzheimer's disease
Hauv kev kho cov tsos mob ntawm Alzheimer's, siv ntau hom tshuaj, suav nrog: cov tshuaj tiv thaiv kab mob (txhim kho lub peev xwm paub), ua kom lub hlwb metabolism, cov tshuaj psychostimulating, txhim kho cerebral ncig, txo cov ntshav siab, anticoagulants, tiv thaiv cerebral hypoxia, vitamins, anti-inflammatory. tshuaj, tshuaj psychotropic.
Hmoov tsis zoo, tseem tsis tau muaj kev kho mob rau qhov ua rau Alzheimer's disease. Ib txoj kev kho mob feem ntau yog nce qhov zoo ntawm conductivity nyob rau hauv lub cholinergic system - feem ntau cuam tshuam los ntawm tus kab mob no.
Discovery nyob rau hauv 1986 neuronal kev loj hlob factor (NGF) Nws coj kev cia siab tshiab rau qhov tshwm sim ntawm cov tshuaj zoo tshiab hauv cov kab mob neurodegenerative. NGF exerts trophic (txhim kho txoj sia nyob) thiab triopic (stimulates txoj kev loj hlob) cuam tshuam rau ntau tus neeg neuronal, tiv thaiv kev puas tsuaj rau paj hlwb. Qhov no tau qhia tias NGF tuaj yeem yog tus neeg sib tw muaj peev xwm los kho Alzheimer's kab mob. Hmoov tsis zoo, NGF yog cov protein uas tsis hla cov hlab ntsha-hlwb thiab yuav tsum tau muab tshuaj intracerebrally. Hmoov tsis zoo, kev txhaj tshuaj ncaj qha ntawm NGF rau hauv cov kua dej hauv lub paj hlwb ventricles ua rau muaj kev phiv loj heev.
Qee qhov kev tshawb fawb kuj qhia tias Cov tshuaj los ntawm pawg phosphodiesterase inhibitors tej zaum yuav yog ib qho tshuaj zoo hauv inhibiting kev loj hlob thiab txo cov tsos mob ntawm Alzheimer's disease. Ib pawg ntawm cov kws tshawb fawb ntawm Columbia University, coj los ntawm Ottavio Arancio thiab Michael Shelanski, pom tias kev kho mob nrog rolipram (cov tshuaj siv los kho kev nyuaj siab hauv qee lub tebchaws) txhim kho kev nco thiab kev paub. Ntxiv mus, cov tshuaj no muaj txiaj ntsig tsis yog nyob rau theem pib ntawm tus kab mob, tab sis kuj rau cov neeg mob Alzheimer's siab heev. Rolipram yog ib qho phosphodiesterase inhibitor. Phosphodiesterase yog lub luag haujlwm rau kev tawg ntawm cov teeb liab molecule cAMP, uas txhawb kev loj hlob ntawm cov paj hlwb. Rolipram inhibits kev tawg ntawm cAMP los ntawm inhibiting phosphodiesterase kev ua haujlwm, uas ua rau cAMP mus rau hauv cov ntaub so ntswg puas. Yog li ntawd, cov txheej txheem xav tau los tsim cov paj hlwb puas tuaj yeem tshwm sim.
Los ntawm kev siv lub hlwb siv zog, peb tiv thaiv nws tawm tsam cov txheej txheem neurodegenerative thiab tib lub sijhawm induce neurogenesis, yog li ua rau cov tub ntxhais hluas ntawm peb lub siab ntev thiab ua rau muaj feem ntawm kev txawj ntse ntxiv rau tag nrho peb lub neej. Yog li kev xav tsis yog peb lub neej xwb, tab sis kuj yog peb txoj kev noj qab haus huv.
Nyeem ntxiv txog kev tiv thaiv kev noj haus rau Alzheimer's!
Ntawv nyeem: Krzysztof Tokarski, MD, PhD, tus kws tshawb fawb ntawm lub koom haum ntawm Pharmacology ntawm Polish Academy of Sciences hauv Krakow
Tus tswv cuab A., Cov tswv cuab AC: Kev Kho Mob hauv Neurology. Compendium. PZWL Medical Publishing, 2010
Gong BI, Vitolo OV, Trinchese F, Liu S, Shelanski M, Arancio O: Kev txhim kho tsis tu ncua hauv kev sib txuas lus thiab kev txawj ntse hauv tus qauv Alzheimer nas tom qab kho rolipram. Clin Invest. 114, 1624-34, 2004
Kozubski W., Liberski PP: Neurology ”PZWL, 2006.
Longstsaff A .: Cov lus qhuab qhia luv luv. Neurobiology. Polish Scientific Publishers PWN, Warsaw, 2009
Nalepa I: “Hais txog cov hauv paus hniav ntawm cov kab mob neurodegenerative” Lub Rooj Sib Tham “Lub Limtiam Lub Hlwb”, Krakow 11 – 17.03. Xyoo 2002
Szczeklik A .: Internal kab mob. Kev Siv Tshuaj, 2005
Vetulani J.: Kev Pom Zoo ntawm Alzheimer's Disease Therapy. XX Lub Caij Ntuj Sov Lub Tsev Kawm Ntawv ntawm Lub Tsev Kawm Ntawv ntawm Pharmacology ntawm Polish Academy of Sciences, 2003