Le Cov tsos mob Gougerot-Sjögren (tshaj tawm sjeu-greunne), uas yog ib feem ntawm cov kab mob qhuav, yog mob hnyav ntawm keeb kwm autoimmune, piv txwv li txuas nrog cov tshuaj tiv thaiv kab mob tiv thaiv kab mob hauv qee yam ntawm lub cev, qhov no yog cov qog qog, zais cov kua hauv daim tawv nqaij los yog cov hnoos qeev.

Nws nrhiav pom hnub rov qab mus rau 1933, los ntawm D.^r Henrik Sjögren, kws kho mob Swedish.

Nws qhov kev tshwm sim tau txuas nrog rau kev nkag mus ntawm qee cov qog los ntawm lymphocytes ua rau txo qis hauv lawv cov secretions. Cov qog qaub ncaug ntawm lub qhov ncauj thiab cov qog ua kua dej feem ntau cuam tshuam, lub luag haujlwm rau "mob qhuav". Peb kuj tseem tuaj yeem soj ntsuam qhov txo qis hauv cov hws, sebum tab sis kuj nkag mus rau hauv thiab ua rau lwm yam kabmob xws li lub ntsws, ob lub raum, pob qij txha lossis cov hlab ntsha me.

Gougerot-Sjögren syndrome yog ib qho kab mob uas tsis tshua muaj cuam tshuam rau qis dua ib ntawm 10 tus neeg laus. Cov poj niam raug cuam tshuam ntau dua 000 npaug tshaj txiv neej. Nws feem ntau tshwm sim nyob ib puag ncig hnub nyoog 10 tab sis tuaj yeem tshwm sim ua ntej hnub nyoog 50 thiab 20. 

hom

Tus kab mob tuaj yeem tshwm sim nws tus kheej hauv 2 txoj hauv kev:

• Primary. Cov tsos mob tshwm sim nyob ib leeg. Nov yog rooj plaub 1 zaug hauv 2. Kwv yees li 93% ntawm cov cuam tshuam yog cov poj niam, thiab cov tsos mob feem ntau tshwm sim thaum muaj hnub nyoog 50 xyoos;
• Secondary. Cov tsos mob yog txuam nrog lwm qhov teeb meem autoimmune, feem ntau ntawm cov uas yog mob caj dab rheumatoid.

Ua rau

Qhov ua rau Cov tsos mob Gougerot-Sjögren tsis paub Txawm li cas los xij, tus kab mob tshwm sim los ntawm cov tshuaj tiv thaiv kab mob autoimmune. Qhov laj thawj yog vim li cas tiv thaiv kab mob ntawm lub cev los ua haujlwm tsis zoo thiab tawm tsam nws tus kheej cov ntaub so ntswg tseem tseem ua pa. Ntau qhov kev xav tseem tab tom kawm. Raws li cov kws tshawb fawb, nws yuav zoo li qhov pib ntawm tus mob no xav tau ob qho tib si kev tshuaj ntsuam genetic predisposition thiab tuaj txog ntawm ua rau yam (kis kab mob, hloov pauv hormonal, kev ntxhov siab, thiab lwm yam).

cov Cov tsos mob

Hauv 2/3 ntawm cov xwm txheej tshwm sim cuam tshuam nrog kev koom tes ntawm cov qog qog exocrine cuam tshuam nrog kev koom tes ntawm lwm cov kabmob (qhov no hu ua kab mob hauv lub cev)

Qhov muag qhuav thiab qhov ncauj feem ntau yog thawj zaug tshwm sim. Txawm li cas los xij, lawv tshwm sim tom qab rau cov neeg uas twb muaj mob caj dab lawm. 

Hauv qhov muag, qhov qhuav tuaj yeem ua rau kub hnyiab lossis khaus khaus. Cov tawv muag feem ntau lo ua ke thaum sawv ntxov, thiab ob lub qhov muag rhiab rau lub teeb.

Qhov ncauj qhuav ua rau hais lus, zom thiab nqos tau yooj yim dua. 

Peb kuj tuaj yeem soj ntsuam hnoos qhuav tas li, mob sib koom, mob nqaij, qaug zog

Sicca syndrome tuaj yeem ua rau nyuaj ntawm qhov muag ntawm qhov muag los ntawm blepharitis lossis keratitis thiab ntawm qhov ncauj los ntawm kev puas tsuaj rau cov pos hniav, kab noj hniav, kev txav mus los ntawm ແຂ້ວ, kab mob txhab, kis kab mob thib ob tshwj xeeb los ntawm mycoses. Ib tus tuaj yeem soj ntsuam qhov ua kom lub siab ua haujlwm ntawm cov qog parotid, hloov pauv lossis tsis yog.

Qhov tshwm sim ntawm cov qog ntxiv cuam tshuam txog cov pob qij txha (ib ntawm 2), Raynaud's syndrome (ntiv tes dhau los ua cov tshuaj dawb rau qhov txias). Lwm qhov kev tawm tsam hnyav dua tab sis tsawg dua, ntawm lub ntsws, lub raum, tawv nqaij lossis sab hauv nruab nrog cev. 

Kev qaug zog yog ntau heev, thiab nrog rau qhov mob sib kis.

diagnostic

Kev kuaj mob yog qhov nyuaj vim tus neeg tsis muaj tag nrho cov tsos mob thiab cov no tuaj yeem cuam tshuam nrog lwm yam mob lossis mus rau kev kho mob.

Kev tshuaj xyuas ntau yam yog qhov tseem ceeb: tshawb nrhiav autoantibodies hauv cov ntshav (anti-SS-A, anti-SS-B antibodies), kev tshuaj xyuas ntawm kev tsim cov qog ua qog uas siv cov ntawv lim (Schirmer's test), kev soj ntsuam ntawm daim nyias nyias uas npog lub qhov muag los ntawm staining nrog rose bengal thiab kuaj qaub ncaug los ntsuas qhov qhuav ntawm lub qhov ncauj thiab qhov ua piv txwv ntawm lymphocytic nodules ntawm qhov hnoos qeev; ua nyob rau hauv lub qhov ncauj salivary qog, tus cwj pwm no tsis yog txhoj puab heev thiab tsis mob. Kev kuaj mob yog ua los ntawm kev ua ke ntawm tus lej ntawm cov tsos mob thiab kab mob lom no. 

Tus kws kho mob tseem tuaj yeem qhia tshuaj ntsuam xyuas lwm qhov chaw ntawm tus kab mob lossis lwm yam kab mob autoimmune.

Thaum lub sijhawm kuaj mob, tus kws kho mob nug tus neeg mob txog nws lub xeev kev noj qab haus huv, hom tshuaj uas nws tab tom noj, thiab tseem hais txog kev noj zaub mov thiab dej ntau npaum cas thiab lwm yam dej haus tau noj txhua hnub.