Hypogammaglobulonemia yog qhov txo qis hauv qib ntawm gamma-globulins lossis immunoglobulins, cov tshuaj muaj lub luag haujlwm tseem ceeb hauv kev tiv thaiv kab mob. Cov kab mob lom no tuaj yeem yog vim kev noj qee yam tshuaj lossis ntau yam pathologies, qee qhov yuav tsum tau kuaj xyuas sai. 

Hypogammaglobulinemia yog txhais los ntawm qib gamma-globulin tsawg dua 6 g / l ntawm plasma protein electrophoresis (EPP). 

Gamma globulins, tseem hu ua immunoglobulins, yog cov khoom tsim los ntawm cov qe ntshav. Lawv muaj lub luag haujlwm tseem ceeb hauv lub cev tiv thaiv. Hypogammaglobumonemia ua rau muaj kev txo qis hauv kev tiv thaiv kab mob ntau dua. Nws yog tsawg.

Kev kuaj xyuas uas tso cai rau kev txiav txim siab ntawm gamma-globulins, thiab lwm yam, yog electrophoresis ntawm cov ntshav cov ntshav los yog cov ntshav plasma proteins. 

Qhov kev ntsuam xyuas no raug sau tseg rau hauv cov ntaub ntawv ntawm kev ua xyem xyav ntawm kev tsis txaus siab ntawm lub cev tsis muaj zog thaum muaj cov kab mob rov ua dua, tshwj xeeb tshaj yog ntawm ENT thiab bronchopulmonary sphere lossis kev tsis zoo ntawm cov xwm txheej, yog tias xav tias muaj ntau yam myeloma (cov tsos mob: mob pob txha, ntshav ntshav, mob ntau zaus…). 

Qhov kev sim no tseem tuaj yeem siv tau tom qab cov txiaj ntsig txawv txav uas qhia tias nce lossis txo qis hauv cov ntshav hauv cov ntshav, cov zis muaj protein ntau, cov ntshav calcium siab, qhov txawv txav ntawm cov qe ntshav liab lossis cov qe ntshav dawb.

Lub electrophoresis ntawm cov ntshav cov protein yog kev kuaj xyuas uas ua rau nws muaj peev xwm ntsuas cov gamma globulins. 

Qhov kev kuaj mob niaj hnub no (cov qauv ntshav, feem ntau yog los ntawm lub luj tshib) tso cai rau kom muaj nuj nqis ntawm ntau yam protein ntau ntawm cov ntshav (albumin, alpha1 thiab alpha2 globulins, beta1 thiab beta2 globulins, gamma globulin). 

Lub electrophoresis ntawm cov ntshav cov protein yog ib qho yooj yim kev ntsuam xyuas uas ua rau nws muaj peev xwm mus ntes thiab koom nyob rau hauv kev saib xyuas ntawm ntau pathologies: inflammatory syndromes, tej yam mob qog noj ntshav, physiological los yog noj zaub mov tsis zoo.

Nws coj mus rau qhov tsim nyog kev ntsuam xyuas ntxiv (immunofixation thiab / lossis kev ntsuam xyuas tshwj xeeb ntawm cov proteins, kev ntsuam xyuas hematological, raum lossis kev tshawb nrhiav digestive).

Qhov kev tshawb pom ntawm hypogammaglobulonemia tuaj yeem yog vim kev noj tshuaj (qhov ncauj corticosteroid therapy, immunosuppressants, anti-epileptics, qog chemotherapy, thiab lwm yam) los yog ntau yam pathologies. 

Kev ntsuam xyuas ntxiv tso cai rau kev kuaj mob thaum txiav txim siab txog tshuaj. 

Txhawm rau txheeb xyuas cov kab mob uas yog kev kuaj mob xwm txheej ceev (lub teeb saw myeloma, lymphoma, mob myeloid leukemia), peb qhov kev ntsuam xyuas tau ua tiav: kev tshawb nrhiav qog nqaij hlav (lymphadenopathy, hepato-splenomegaly), kuaj pom cov proteinuria thiab suav ntshav.

Thaum cov xwm txheej kuaj mob no tau txiav txim siab lwm yam ua rau hypogammaglobulonemia tau hais: nephrotic syndrome, exudative enteropathies. Cov ua rau exudative enteropathies tuaj yeem ua rau mob plab hnyuv, kab mob celiac nrog rau cov qog nqaij hlav plab lossis qee cov qog ntshav qog ntshav xws li lymphoma lossis thawj amyloidosis (LA, lub teeb saw amyloidosis ntawm immunoglobulins).

Tsis tshua muaj, hypogammaglobulonemia tuaj yeem tshwm sim los ntawm kev tiv thaiv kab mob humoral.

Kev noj zaub mov tsis zoo lossis Cushing's syndrome kuj tuaj yeem ua rau hypogammaglobulonemia.

Kev kuaj ntxiv tso cai rau kev kuaj mob (thoraco-abdominal-pelvic scanner, suav ntshav, ua haujlwm mob, albuminemia, 24-teev proteinuria, kev txiav txim siab hnyav ntawm immunoglobulins thiab ntshav immunofixation)

Kev kho yog nyob ntawm qhov ua rau. 

Nws tuaj yeem teeb tsa kev tiv thaiv kev kho mob rau cov neeg muaj kev txom nyem los ntawm hypogammaglobulinemia: kev txhaj tshuaj tiv thaiv kab mob pneumococcal thiab lwm yam tshuaj tiv thaiv, tshuaj tua kab mob tiv thaiv kab mob, hloov pauv hauv polyvalent immunoglobulins.