Uricemia yog qhov concentration ntawm uric acid hauv cov ntshav. Qhov no uric acid tshwm sim los ntawm degradation ntawm nitrogenous khoom, raws li catabolism ntawm nucleic acids uas muaj nyob rau hauv lub cev (DNA thiab RNA), los yog kev puas tsuaj ntawm purines absorbed los ntawm cov zaub mov. Uric acid yog tshem tawm feem ntau los ntawm cov zis. Kev nce qib ntawm uric acid, hu ua hyperuricemia, tuaj yeem ua rau mob gout lossis urolithiasis. Hypo-uricemia qee zaum pom tom qab noj qee yam kev kho mob. Kev coj noj coj ua zoo yuav pab tswj tau uricemia.

Uricemia yog theem ntawm uric acid nyob rau hauv cov ntshav plasma. Qhov no uric acid yog ib yam khoom uas tshwm sim los ntawm degradation ntawm nitrogenous khoom: yog li, nws yog los ntawm catabolism ntawm nucleic acids tam sim no nyob rau hauv lub cev nyob rau hauv daim ntawv ntawm DNA thiab RNA, los yog generated los ntawm degradation ntawm purines noj thaum noj zaub mov. Uric acid yog cov khoom pov tseg uas tsim los ntawm lub cev, tshwj xeeb tshaj yog thaum lub sijhawm tuag thiab rov ua dua tshiab ntawm tes, nws degrades DNA thiab RNA molecules (cov molecules uas nqa cov ntaub ntawv caj ces ntawm tus neeg thiab tso cai rau nws txhais ua cov proteins).

Uric acid yog pom nyob rau hauv cov ntshav, qhov twg nws yog faib ntawm plasma thiab cov qe ntshav, thiab nyob rau hauv cov ntaub so ntswg. Uric acid tsis tuaj yeem hloov pauv, xws li noog, mus rau hauv allantoin: qhov tseeb, tib neeg tsis muaj enzyme muaj peev xwm ua kom tshem tawm cov uric acid los ntawm txoj kev ntawm allantoin. Yog li ntawd, cov uric acid no yuav tawm hauv tib neeg los ntawm cov zis.

• Yog tias cov ntshav uric acid muaj ntau, nws tuaj yeem ua rau hauv cov pob qij txha thiab ua rau mob ua rau gout tawm tsam, uas yog mob heev.
• Yog tias nws khaws cia hauv cov zis, nws tuaj yeem ua rau urolithiasis, thiab los ntawm lub xub ntiag ntawm pob zeb, kuj ua rau mob hnyav.

Uricemia yuav tsum tau ua yog tias tus kws kho mob xav tias muaj kev nce hauv uric acid hauv cov ntshav. Yog li ntawd, qhov kev tshawb fawb txog roj ntsha no yuav ua tau tshwj xeeb:

• yog tias tus kws kho mob xav tias muaj qhov tshwm sim ntawm gout, thaum tus neeg mob muaj mob pob qij txha;
• txhawm rau saib xyuas qee yam kab mob uas muaj hyperuricemia, xws li raum tsis ua haujlwm lossis qee yam kab mob ntshav; 
• tom qab noj qee yam tshuaj xws li diuretics uas cuam tshuam cov zis tshem tawm ntawm uric acid; 
• nyob rau hauv cov ntaub ntawv ntawm overeating, uas tuaj yeem ua rau nce qib ntawm uric acid; 
• saib xyuas hypo-uricemia;
• thaum cev xeeb tub, txhawm rau kuaj pom muaj hyperuricemia;
• nyob rau hauv cov neeg uas muaj lub raum pob zeb ntawm uric acid los yog urate;
• rau kev saib xyuas ntawm cov neeg uas twb tau nthuav tawm qhov siab uricemia, txhawm rau txheeb xyuas qhov txaus ntshai ntawm lub raum teeb meem.

Qhov kev kuaj uric acid no feem ntau yuav ua ke nrog kev kawm ntawm lub raum kev ua haujlwm, los ntawm kev ntsuas qib creatinine hauv cov ntshav.

Kev txiav txim siab lom neeg ntawm uric acid yog ua los ntawm cov txheej txheem enzymatic, ntawm cov ntshav, tom qab kuaj ntshav. Cov ntshav no yog coj los ntawm tus neeg mob yoo mov, thiab deb ntawm cov dej noj. Lub venipuncture feem ntau yog ua nyob rau hauv lub crease ntawm lub luj tshib. Nws yog ua nyob rau hauv ib lub chaw soj ntsuam kev kho mob, feem ntau nyob rau hauv lub zos, raws li ib tug tshuaj kho mob. Qhov nruab nrab, cov txiaj ntsig muaj nyob hauv 24 teev ntawm kev sau.

Uric acid circulates nyob rau hauv cov ntshav ntawm ib txwm muaj nyob rau hauv cov poj niam ntawm 150 thiab 360 μmol ib liter, thiab nyob rau hauv cov txiv neej ntawm 180 thiab 420 μmol ib liter. Cov theem ib txwm nyob rau hauv cov neeg laus, hauv mg ib liter, feem ntau suav hais tias yog nyob nruab nrab ntawm 25 txog 60 hauv cov poj niam thiab 35 txog 70 hauv cov txiv neej. Hauv cov menyuam yaus, nws yuav tsum nyob nruab nrab ntawm 20 thiab 50 mg ib liter (piv txwv li 120 txog 300 µmol ib liter).

Nyob rau hauv cov kev tshwm sim ntawm hyperuricemia, yog li ntawd nrog uric acid concentration ntau dua 360 μmol / liter ntawm cov poj niam thiab ntau dua 420 μmol / liter ntawm txiv neej, tus neeg mob yuav muaj kev pheej hmoo ntawm gout los yog urolithiasis.

• Gout yog kab mob sib koom ua ke, uas feem ntau cuam tshuam rau cov ntiv taw loj, tab sis qee zaum kuj pob taws thiab pob qij txha. Nws yog tshwm sim los ntawm kev nce hauv uric acid cov ntsiab lus hauv cov ntshav uas ua rau cov pob qij txha hauv peripheral ntawm urate crystals, thiab o. Kev kho mob ntawm qhov mob hnyav feem ntau yog nyob ntawm colchicine. Hyperuricemia tuaj yeem tiv thaiv los ntawm kev tshem tawm txhua yam ua rau hyperuricemia, thiab los ntawm xanthine oxidase inhibitors (cov enzyme no hloov cov molecule hu ua xanthine rau hauv uric acid).

   

• Urolithiasis yog lub xub ntiag ntawm pob zeb hauv txoj hauv kev ntawm cov zis tso zis, tshwm sim los ntawm kev tsim cov pob zeb.

Hypo-uricemia, piv txwv li, uric acid concentration tsawg dua 150 µmol / liter hauv cov poj niam thiab 180 µmol / liter hauv cov txiv neej, feem ntau yog pom thaum kho urico-tso lossis urico-braking.

Nyob rau hauv ancient sij hawm, lub sij hawm ntawm gout tau qhia raws li ib tug tshwm sim ntawm overeating thiab haus. Tab sis nws tsuas yog nyob rau hauv kaum xyoo dhau los uas kev nkag siab dav ntawm cov khoom noj khoom haus cuam tshuam nrog hyperuricemia thiab gout tau tshwm sim. Yog li, feem ntau, overfeeding ua rau muaj kev nce hauv uric acidemia ntawm qhov kev txiav txim ntawm 10 mg / ml. Tshwj xeeb tshaj yog, nyob rau hauv cov txiv neej laus uas muaj uricemia ntawm 60 thiab 70 mg / ml, qhov kev nce no tuaj yeem ua rau mob gout.

Kev rog rog, nqaij liab ntau dhau hauv cov zaub mov thiab dej cawv twb tau lees paub tias ua rau mob gout, txij li thaum ancient sij hawm. Ntawm qhov tod tes, zaub thiab nroj tsuag nplua nuj hauv purines tsis koom nrog, raws li ntau qhov kev tshawb fawb tau pom. Ntawm qhov tod tes, cov kev pheej hmoo tshiab, uas tseem tsis tau lees paub, tau raug txheeb xyuas, suav nrog fructose thiab dej qab zib. Thaum kawg, cov ntsiab lus tiv thaiv kuj tau tshaj tawm, tshwj xeeb yog kev noj cov khoom noj siv mis skimmed.

Gout yog tus cwj pwm tsis yog los ntawm kev nce ntxiv ntawm uric acid, tuaj yeem tshwm sim ntawm kev mob caj dab thiab kev puas tsuaj mus ntev, tab sis kuj tuaj yeem cuam tshuam nrog kev mob hnyav, thiab muaj kev pheej hmoo ntawm cov kab mob plawv. Kev coj noj coj ua noj qab haus huv yuav pab tswj tau uricemia zoo dua thiab txo cov kab mob cuam tshuam nrog nws.