Qhov tseeb hais tias nyob rau hauv lub neej yav tom ntej oncology thaum kawg yuav tsum tsis txhob ua ib kab lus, cov kws tshawb fawb dua pib tham. Ntxiv mus, qhov kev tshawb pom zaum kawg los ntawm cov kws tshawb fawb los ntawm University of Notre Dame (South Bend, United States) qhia tias qhov kev ua tiav tiag tiag tuaj yeem ua tau txawm tias kho cov mob qog noj ntshav txaus ntshai tshaj plaws, uas nyuaj heev rau cov kev kho mob uas twb muaj lawm.
Ib tsab xov xwm tshaj tawm rau hauv Medical Xpress lub vev xaib tham txog cov khoom tshwj xeeb ntawm RIPK1 protein enzyme. Nws yog ib tus neeg koom nrog hauv cov txheej txheem ntawm cell necrosis. Txawm li cas los xij, raws li cov kws tshawb fawb tau pom, cov protein no tseem tuaj yeem thaiv kev txhim kho ntawm malignant neoplasms thiab tshwm sim ntawm metastases. Yog li ntawd, qhov sib xyaw no tuaj yeem dhau los ua ib qho ntawm cov tshuaj uas tau npaj rau kev kho mob ntawm cov mob qog noj ntshav txaus ntshai tshaj plaws.
Raws li nws tau paub los ntawm kev tshawb fawb, RIPK1 pab txo qis cov mitochondria hauv hlwb. Cov no yog cov organelles lub luag hauj lwm rau kev siv lub zog pauv. Thaum lawv tus lej txo qis, qhov hu ua "oxidative stress" pib tsim. Ib tug loj npaum li cas ntawm reactive oxygen hom ua rau cov proteins, DNA thiab lipids, vim hais tias cov txheej txheem ntawm cell self-destruction pib. Hauv lwm lo lus, cov txheej txheem ntawm necrosis lossis cell apoptosis pib.
Cov kws tshawb fawb nco ntsoov tias necrosis yog cov txheej txheem pathological uas lub cell nws tus kheej raug rhuav tshem, thiab kev tso tawm ntawm nws cov ntsiab lus tshwm sim rau hauv qhov chaw intercellular. Yog hais tias lub cell tuag raws li nws cov kev pab cuam caj ces, uas yog hu ua apoptosis, ces nws cov seem raug tshem tawm ntawm cov ntaub so ntswg, uas tshem tawm qhov yuav tshwm sim ntawm o.
Raws li cov kws tshawb fawb Asmeskas, RIPK1 tuaj yeem dhau los ua ib qho ntawm cov catalysts rau cov txheej txheem "tswj cell tuag". Hauv lwm lo lus, nws tuaj yeem siv los ua riam phom ntawm "kev puas tsuaj" - txhawm rau siv "kev tawm tsam" rau cov qog nqaij hlav nrog cov protein enzyme. Qhov no yuav pab nres cov txheej txheem ntawm metastasis thiab nce hauv neoplasm.