Le fibrinogen yog ib tug protein ntshav uas plays lub luag haujlwm hauv coagulation. Nws koom nrog kev cob qhia ntawm ntshav txhaws thiab kuj modulates cov kev ua ntawm cov ntshav platelets thiab cell ntawm lub hlab ntsha. Nyob rau hauv qhov kev txiav txim ntawm lwm cov protein, lub thrombin, nws hloov mus rau hauv fibrin cov

Nws yog synthesized los ntawm cov hlwb ntawm lub siab. Nws qib hauv cov ntshav ib txwm txawv ntawm 2 mus rau 4 g / l. Txawm li cas los, lub synthesis ntawm no protein tej zaum yuav nce ntxiv los ntawm kev ntxhov siab, thaum cev xeeb tub, lossis tom qab txhaj tshuaj lossis cov tshuaj hormones loj hlob. Kev nce qib ntawm fibrinogen hauv cov ntshav kuj yog qhov qhia tau hais tias muaj mob.

Qhov kev ntsuam xyuas fibrinogen yog qhia los tshuaj xyuas cov ntshav txhaws (piv txwv li thaum tsis tau piav qhia los ntshav lossis ” defibrination syndrome », Ua raws li kev coagulation abnormality).

Muaj peb qhov kev yug me nyuam hauv qib fibrinogen:

• LUBafibrinogenemia, uas yog qhov ua tsis tiav ntawm fibrinogen. Cov kab mob tsawg no ua rau los ntshav hnyav uas tshwm sim thaum yug los
• LUBhypofibrinogenemia, sib piv rau qhov txo qis hauv qib ntawm fibrinogen hauv cov ntshav (qhov no yog qhov tsis xws luag hauv kev zais cia, feem ntau)
• La dysfibrinogenemia, uas yog qhov txawv txav ntawm cov protein.

Kev kuaj ntshav fibrinogen kuj tseem yuav pab tau thaum:

• cov tsos mob mob
• daim siab tsis ua haujlwm (ua rau txo qis hauv qib fibrinogen)
• txhawm rau saib xyuas cov txiaj ntsig ntawm qhov kev kho mob hu ua "fibrinolytic", npaj kom yaj cov ntshav txhaws thaum muaj thrombosis.

Kev noj tshuaj fibrinogen yog ua tiav ntawm cov ntshav venous (xws li ntshav), hauv chav kuaj mob. Dosage yog ib qho kev ntsuas niaj hnub thiab cov txiaj ntsig feem ntau tau txais hauv ib hnub.

Tus kws kho mob tsuas yog tus uas tuaj yeem txhais cov txiaj ntsig ntawm kev tshuaj ntsuam.

Feem ntau, ntau tshaj ntawm fibrinogen (hyperfibrinogenemia) tuaj yeem pom thaum muaj mob, thaum muaj qee yam kab mob sib kis (pneumonia, thiab lwm yam), thaum muaj mob rheumatic fever lossis kab mob autoimmune (lupus), tom qab myocardial infarction, thiab lwm yam.

Hloov pauv, hypofibrinogenemia (txo qis hauv qib fibrinogen) tuaj yeem cuam tshuam txog kab mob caj ces, mob siab tsis ua haujlwm (hepatitis, cirrhosis), coagulation disorders (disseminated intravascular coagulation lossis defibrination syndrome) lossis "fibrinolysis", piv txwv li vim mob qog noj ntshav.