Lo lus SIBO sawv cev rau "cov kab mob hauv plab me me" thiab hais txog cov kab mob loj ntawm cov hnyuv me, uas yog tus cwj pwm los ntawm cov kab mob ntau dhau ntawm cov hnyuv thiab malabsorption. Cov tsos mob tshwm sim feem ntau yog raws plab, roj thiab cov tsos mob ntawm malabsorption. Cov yam tseem ceeb uas ua rau cov kab mob loj hlob tuaj yog anatomical (diverticulosis, dig muag voj, thiab lwm yam) los yog ua haujlwm (kev cuam tshuam hauv plab hnyuv, tsis muaj gastric acid secretion). Kev kho mob suav nrog kev noj zaub mov tsis muaj rog, tsis muaj carbohydrates, kev tswj xyuas qhov tsis txaus, kev kho mob dav dav, thiab tshem tawm cov txiaj ntsig los tiv thaiv kev rov tshwm sim.

Lo lus SIBO sawv cev rau "cov kab mob plab hnyuv me me" lossis cov kab mob loj dua ntawm txoj hnyuv me. Nws yog tus cwj pwm los ntawm cov kab mob ntau dhau hauv cov hnyuv (> 105 / ml) uas tuaj yeem ua rau malabsorption tsis zoo, piv txwv li kev nqus tsis txaus ntawm cov khoom noj.

Hauv cov xwm txheej ib txwm muaj, qhov sib thooj ntawm cov hnyuv me muaj tsawg dua 105 cov kab mob / ml, feem ntau yog aerobic Gram-zoo kab mob. Qhov no tsis tshua muaj kab mob concentration yog tswj los ntawm:

• cov nyhuv ntawm ib txwm plab hnyuv contractions (los yog peristalsis);
• ib txwm gastric acid secretion;
• hnoos qeev;
• secretory immunoglobulins A;
• ua haujlwm ileocecal valve.

Nyob rau hauv cov ntaub ntawv ntawm cov kab mob overgrowth, ib tug tshaj ntawm cov kab mob,> 105 / ml, yog pom nyob rau hauv lub proximal txoj hnyuv. Qhov no tuaj yeem txuas rau:

• abnormalities los yog anatomical hloov nyob rau hauv lub plab thiab / los yog cov hnyuv me (diverticulosis ntawm cov hnyuv me, phais dig muag loops, post-gastrectomy tej yam kev mob, strictures los yog ib feem obstructions) uas txhawb slowing ntawm cov hnyuv, ua rau cov kab mob overgrowth; 
• lub cev muaj zog ntawm lub plab zom mov cuam tshuam nrog ntshav qab zib neuropathy, scleroderma, amyloidosis, hypothyroidism lossis idiopathic plab hnyuv pseudo-obstruction uas yuav txo tau cov kab mob khiav tawm;
• qhov tsis muaj cov kua qaub hauv plab (achlorhydria), uas tej zaum yuav yog tshuaj los yog phais keeb kwm.

Cov kab mob ntau tshaj plaws rau cov kab mob loj hlob hauv cov hnyuv muaj xws li:

• Streptococcus sp;
• Bacteroides sp;
• Escherichia coli;
• Staphylococcus sp;
• Klebsiella sp;
• thiab Lactobacillus.

Cov kab mob ntau dhau no txo ​​qis kev nqus ntawm cov plab hnyuv siab raum thiab noj cov zaub mov, suav nrog carbohydrates thiab vitamin B12, uas tuaj yeem ua rau carbohydrate malabsorption thiab as-ham thiab vitamin deficiency. Ntxiv mus, cov kab mob no kuj ua rau cov kua tsib ntsev los ntawm kev hloov lawv, lawv tiv thaiv kev tsim ntawm micelles uas ua rau malabsorption ntawm lipids. Cov kab mob loj zuj zus thaum kawg ua rau cov kab mob ntawm txoj hnyuv mucosa. 

Ntau tus neeg mob tsis muaj tsos mob. Ntxiv rau qhov poob phaus los yog qhov tsis txaus ntawm cov as-ham thiab cov vitamins uas muaj roj-soluble (tshwj xeeb yog cov vitamins A thiab D), cov tsos mob feem ntau suav nrog:

• tsis xis nyob hauv plab;
• ntau dua lossis tsawg dua raws plab;
• steatorrhea, uas yog, ib qho txawv txav ntawm cov lipids hauv cov quav, uas tshwm sim los ntawm malabsorption ntawm lipids thiab kev puas tsuaj rau cov mucous membranes;
• tsam plab;
• Cov roj ntau dhau, tshwm sim los ntawm cov pa roj uas tsim los ntawm fermentation ntawm carbohydrates.

Kev kho tshuaj tua kab mob yuav tsum tau muab tso rau hauv qhov chaw, tsis yog txhawm rau tshem tawm cov kab mob flora tab sis hloov kho kom tau txais kev txhim kho ntawm cov tsos mob. Vim muaj cov kab mob polymicrobial ntawm cov hnyuv, cov tshuaj tua kab mob dav dav yog tsim nyog los npog tag nrho cov kab mob aerobic thiab anaerobic.

Kev kho mob ntawm SIBO yog li no raws li kev noj, rau 10 mus rau 14 hnub, qhov ncauj, ib lossis ob ntawm cov tshuaj tua kab mob hauv qab no:

• Amoxicillin / clavulanic acid 500 mg 3 zaug / hnub;
• Cephalexin 250 mg 4 zaug / hnub;
• Trimethoprim / sulfamethoxazole 160 mg / 800 mg ob zaug / hnub;
• Metronidazole 250-500 mg 3 los yog 4 zaug / hnub;
• Rifaximin 550 mg 3 zaug ib hnub twg.

Qhov dav-spectrum tshuaj tua kab mob no tuaj yeem ua rau cyclical lossis hloov kho, yog tias cov tsos mob zoo li rov tshwm sim.

Nyob rau tib lub sijhawm, cov yam ntxwv uas nyiam cov kab mob loj dua (anatomical thiab functional abnormalities) yuav tsum raug tshem tawm thiab kev hloov pauv ntawm cov zaub mov raug pom zoo. Qhov tseeb, cov kab mob ntau dhau feem ntau metabolize carbohydrates hauv plab hnyuv lumen es tsis yog lipids, noj zaub mov muaj roj thiab tsis muaj fiber ntau thiab carbohydrate - tsis muaj lactose - tau pom zoo. Vitamin deficiency, tshwj xeeb tshaj yog vitamin B12, kuj yuav tsum tau kho.