Acromegaly yog kab mob tshwm sim los ntawm kev tsim cov tshuaj loj hlob ntau dhau (tseem hu ua somatotropic hormone lossis GH rau Kev Loj Hlob Hormon). Qhov no ua rau muaj kev hloov pauv ntawm lub ntsej muag, nce hauv qhov loj me ntawm txhais tes thiab taw thiab kuj ntawm ntau lub nruab nrog cev, uas yog qhov ua rau muaj cov tsos mob tseem ceeb thiab cov cim qhia ntawm tus kab mob.

Nws yog qhov xwm txheej tsis tshua muaj tshwm sim, cuam tshuam ib puag ncig 60 txog 70 kis rau ib lab tus neeg nyob hauv, uas sawv cev rau 3 txog 5 kis rau ib lab tus neeg nyob hauv ib xyoos.

Hauv cov neeg laus, feem ntau yog kuaj pom thaum muaj hnub nyoog 30 txog 40. Ua ntej pub niam mis, qhov nce ntawm GH ua rau gigantism lossis giganto-acromegaly.

Lub hauv paus tseem ceeb ntawm acromegaly yog cov qog nqaij hlav (tsis mob qog noj ntshav) ntawm cov qog pituitary, lub qog (tseem hu ua qog caj pas pituitary), nyob hauv lub hlwb thiab uas ib txwm zais ntau cov tshuaj hormones suav nrog GH.