Lub follicle stimulating hormone, los yog FSH, yog ib qho tseem ceeb hormone ntawm fertility ntawm txiv neej thiab poj niam. Qhov no yog vim li cas thaum lub sij hawm kuaj fertility, nws tus nqi yog soj ntsuam systematically.

Hauv poj niam

HSF tshwm sim hauv thawj theem ntawm lub zes qe menyuam, hu ua theem follicular. Thaum lub sij hawm no, uas pib rau thawj hnub ntawm kev coj khaub ncaws thiab xaus thaum lub sij hawm ntawm ovulation, lub hypothalamus secretes ib tug neurohormone, GnRH (gonadotropin tso cov tshuaj hormones). Cov tshuaj tiv thaiv kab mob yuav ua raws li:

• GnRH txhawb nqa lub caj pas pituitary, uas nyob rau hauv cov lus teb secretes FSH;
• nyob rau hauv tus ntawm FSH, nyob ib ncig ntawm nees nkaum lub zes qe menyuam follicles yuav pib loj hlob;
• cov follicles maturing yuav nyob rau hauv lem secrete estrogen, lub luag hauj lwm rau thickening ntawm lub tsev menyuam hauv ob sab phlu thiaj li yuav npaj lub tsev menyuam kom tau txais ib tug muaj peev xwm fertilized qe;
• Nyob rau hauv lub cohort, ib tug follicle, hu ua dominant follicle, ua tiav ovulation. Lwm tus yuav raug tshem tawm;
• Thaum xaiv qhov tseem ceeb preovulatory follicle, estrogen secretion nce sharply. Qhov kev nce no ua rau muaj qhov nce ntxiv hauv LH (luteinizing hormone) uas yuav ua rau ovulation: cov follicle ruptures paub tab thiab tso tawm oocyte.

Nyob rau ntawm qhov chaw ntawm cov saw hlau no, FSH yog qhov tseem ceeb tshaj plaws rau kev xeeb tub.

Hauv tib neeg

FSH koom nrog hauv spermatogenesis thiab tso tawm ntawm testosterone. Nws txhawb cov Sertoli hlwb uas tsim cov phev nyob rau hauv lub testes.

Hauv poj niam, Kev noj ntau npaum ntawm FSH tuaj yeem raug sau rau hauv ntau qhov xwm txheej:

• nyob rau hauv cov kev tshwm sim ntawm thawj amenorrhea thiab / los yog lig puberty: ib tug ua ke koob tshuaj ntawm FSH thiab LH yog nqa tawm nyob rau hauv thiaj li yuav paub qhov txawv ntawm lub hauv paus (qauv keeb kwm ntawm zes qe menyuam) los yog theem nrab (siab keeb kwm: hypothalamus los yog pituitary) hypogonadism;
• nyob rau hauv lub thib ob amenorrhea;
• Thaum muaj teeb meem kev xeeb tub, kev ntsuam xyuas hormonal yog ua nrog ntau npaum li cas ntawm cov tshuaj hormones sib txawv: follicle stimulating hormone (FSH), estradiol, luteinizing hormone (LH), antimulleric hormone (AMH) thiab qee zaum prolactin, TSH (thyroid. ), testosterone. Kev sim rau FSH pab ntsuas zes qe menyuam thiab qhov zoo ntawm ovulation. Nws tso cai rau kom paub yog tias ovulation tsis meej lossis amenorrhea yog vim kev laus ntawm zes qe menyuam lossis kev koom tes hauv qog pituitary.
• Thaum lub cev tsis muaj zog, qhov kev txiav txim siab ntawm FSH tsis pom zoo kom paub meej tias qhov pib ntawm pre-menopause thiab menopause (HAS, 2005) (1).

Hauv tib neeg

Kev ntsuam xyuas FSH tuaj yeem ua tau raws li ib feem ntawm kev ntsuam xyuas fertility, nyob rau hauv lub ntsej muag ntawm spermogram abnormality (azoospermia los yog oligospermia hnyav), thiaj li yuav kuaj tau hypogonadism.

Kev ntsuas hormonal yog coj los ntawm kev kuaj ntshav, tsis yog ntawm lub plab khoob.

• Hauv cov poj niam, kev txiav txim siab ntawm FSH, LH thiab estradiol yog ua nyob rau hnub 2nd, 3rd lossis 4th ntawm lub voj voog nyob rau hauv lub chaw soj nstuam.
• Hauv tib neeg, qhov koob tshuaj FSH tuaj yeem ua tau txhua lub sijhawm.

Hauv poj niam:

• ib qho kev nce hauv FSH thiab LH qhia tau hais tias thawj lub zes qe menyuam tsis ua haujlwm;
• Kev txo qis hauv LH thiab FSH feem ntau qhia txog kev puas tsuaj rau lub caj pas pituitary, thawj lossis theem nrab (cov qog, pituitary necrosis, hypophysectomy, thiab lwm yam);
• Yog tias FSH siab thiab / lossis estradiol qis, qhov txo qis hauv zes qe menyuam raug xav tias yog ("thaum ntxov menopause").

Hauv tib neeg:

• qib FSH siab qhia tau hais tias kev puas tsuaj rau lub qog los yog seminiferous tubular;
• Yog tias nws qis, "siab" kev koom tes (hypathalamus, pituitary) yog xav tias. MRI thiab kuaj ntshav ntxiv yuav ua rau nrhiav pituitary insufficiency.

Hauv poj niam:

• nyob rau hauv cov xwm txheej ntawm zes qe menyuam tsis ua hauj lwm los yog kev koom tes ntawm lub caj pas pituitary, kev kho ntawm zes qe menyuam stimulation yuav muab. Nws lub hom phiaj yog tsim ib lossis ob lub oocytes paub tab. Muaj cov txheej txheem sib txawv, los ntawm qhov ncauj los yog txhaj tshuaj;
• nyob rau hauv cov xwm txheej ntawm lub cev tsis muaj hnub nyoog, kev pub dawb oocyte tuaj yeem muab.

Hauv tib neeg:

• Nyob rau hauv cov xwm txheej ntawm hypogonatotropic hypogonadism (hloov ntawm hypotalamic-pituitary axis) nrog azoospermia lossis oligospermia hnyav, kev kho mob los kho cov spermatogenesis yuav raug sau tseg. Ob hom molecules tuaj yeem siv tau: gonadotropins nrog FSH kev ua haujlwm thiab gonadotropins nrog LH kev ua haujlwm. Cov txheej txheem, uas txawv raws li tus neeg mob, kav ntev li 3 mus rau 4 lub hlis, lossis ntev dua nyob rau qee lub sijhawm.
• Thaum muaj kev hloov pauv phev hnyav thiab qee yam azoospermia (rau qhov nws muaj peev xwm phais tshem cov phev los ntawm lub epididymis lossis testis), IVF nrog ICSI tuaj yeem muab. Cov txheej txheem AMP no muaj kev txhaj tshuaj phev ncaj qha rau hauv cytoplasm ntawm cov laus oocyte;
• Cov phev pub dawb tuaj yeem muab pub rau ob leeg yog tias tsis tuaj yeem rov qab kho cov spermatogenesis.