Cov tshuaj uas inhibit qhov kev ua ntawm lub cev tiv thaiv kab mob protein - gamma interferon thaiv txoj kev loj hlob ntawm melanoma - mob qog noj ntshav txaus ntshai - raws li US cov kws tshawb fawb hauv phau ntawv journal Nature.
Kev raug ultraviolet lub teeb thiab hluav taws xob yog ob lub ntsiab ua rau kev loj hlob ntawm melanoma - feem ntau mob qog noj ntshav ntawm daim tawv nqaij. Hmoov tsis, txog rau tam sim no cov txheej txheem molecular ntawm kev loj hlob ntawm tus mob qog noj ntshav no tsis tau nkag siab tag nrho.
Glenn Merlino thiab cov npoj yaig los ntawm National Cancer Institute hauv Bethesda tau kawm txog qhov cuam tshuam ntawm UVB hluav taws xob hauv nas. Cov kws tshawb fawb tau pom tias UVB ua rau macrophages ntws mus rau hauv daim tawv nqaij. Macrophages yog ib hom ntawm cov qe ntshav dawb, cov hlwb uas tsim cov interferon gamma, cov protein uas cov tshuaj qhia txog kev loj hlob ntawm melanoma.
Inhibition ntawm kev ua ntawm interferon gamma (xws li interferon hom II) nrog kev pab los ntawm cov tshuaj tiv thaiv tsim nyog inhibits qhov txawv txav ntawm daim tawv nqaij loj hlob thiab kev loj hlob ntawm cov qog nqaij hlav, inhibition ntawm interferon I kev ua tsis tau zoo li no.
Hom I interferons tau lees paub tias yog cov tshuaj tiv thaiv kab mob qog noj ntshav thiab ib qho ntawm lawv, interferon alpha, yog siv los kho melanoma. Qhov kev tshawb pom tias gamma interferon muaj qhov cuam tshuam tsis zoo thiab txhawb kev txhim kho qog noj ntshav yog qhov xav tsis thoob. Inhibition ntawm gamma interferon los yog cov proteins uas nws cuam tshuam zoo nkaus li yog lub hom phiaj zoo rau kev kho mob melanoma. (PAP)