Hauv cov txiv neej thiab poj niam, luteinizing hormone lossis LH ua lub luag haujlwm tseem ceeb hauv kev xeeb tub. Nws yog tseeb ib feem ntawm cov tshuaj hormones hu ua gonadotropins, conductors ntawm cov qog nqaij hlav. Ib qho kev tsis sib haum xeeb hauv nws qhov zais cia tuaj yeem yog qhov cuam tshuam rau kev xeeb tub.

Luteinizing hormone los yog LH (luteizing hormone) yog secreted los ntawm lub anterior pituitary. Nws yog ib feem ntawm cov gonadotropins: nws tswj, nrog rau lwm cov tshuaj hormones, cov qog nqaij hlav (gonads), nyob rau hauv cov ntaub ntawv no lub zes qe menyuam nyob rau hauv cov poj niam thiab cov noob qes nyob rau hauv cov txiv neej.

Hauv poj niam

Nrog rau follicle stimulating hormone (FSH), LH ua lub luag haujlwm tseem ceeb hauv lub zes qe menyuam. Nws yog qhov tseeb ntawm LH surge uas yuav ua rau ovulation thaum lub sij hawm muaj kev sib txuas lus:

• lub hypothalamus secretes gnRH (gonadotropin tso cov tshuaj hormones) uas stimulates lub caj pas pituitary;
• nyob rau hauv cov lus teb, lub caj pas pituitary secretes FSH thaum lub sij hawm thawj theem ntawm lub voj voog (los ntawm thawj hnub ntawm kev coj khaub ncaws mus rau ovulation);
• Raws li qhov tshwm sim ntawm FSH, qee qhov ntawm zes qe menyuam cov hauv paus hniav yuav pib loj tuaj. Cov hlwb ntawm zes qe menyuam nyob ib ncig ntawm lub zes qe menyuam hauv plab yuav ua rau cov tshuaj estrogen ntau dua;
• qhov no nce qib ntawm cov tshuaj estrogen hauv cov ntshav ua rau lub hypothalamic-pituitary complex thiab ua rau cov loj heev tso LH;
• Raws li qhov tshwm sim ntawm LH surge, qhov nro hauv lub follicle nce. Nws thiaj li tawg thiab tshem tawm cov oocyte mus rau hauv lub raj: qhov no yog ovulation, uas tshwm sim 24 mus rau 36 teev tom qab LH surge.

Tom qab ovulation, LH tseem ua lub luag haujlwm tseem ceeb. Nyob rau hauv nws cov cawv, lub ruptured zes qe menyuam follicle hloov mus rau hauv lub caj pas hu ua corpus luteum uas nyob rau hauv lem secretes estrogen thiab progesterone, ob yam tshuaj hormones tseem ceeb nyob rau hauv thaum ntxov cev xeeb tub.

Hauv tib neeg

Zoo li lub zes qe menyuam, cov noob qes raug tswj hwm ntawm FSH thiab LH. Lub tom kawg txhawb nqa Leydig hlwb uas yog lub luag haujlwm rau kev tso tawm ntawm testosterone. LH secretion yog qhov tsis tu ncua tom qab puberty.

LH koob tshuaj tuaj yeem raug sau rau hauv ntau qhov xwm txheej:

Hauv poj niam

• nyob rau hauv lub xub ntiag ntawm cov cim qhia ntawm precocious los yog lig puberty;
• nyob rau hauv cov xwm txheej ntawm kev coj khaub ncaws;
• Nyob rau hauv cov ntaub ntawv ntawm kev xeeb tub tsis yooj yim: kev ntsuam xyuas hormonal yog systematically ua raws li ib feem ntawm kev ntsuam xyuas infertility. Nws suav nrog kev txiav txim siab ntawm LH;
• Kev kuaj xyuas LH surge nyob rau hauv cov zis kuj ua rau nws muaj peev xwm txheeb xyuas hnub ntawm ovulation, thiab yog li ntawd txiav txim siab nws fertility qhov rais nyob rau hauv thiaj li yuav optimize nws muaj feem yuav xeeb tub. Qhov no yog lub hauv paus ntsiab lus ntawm kev kuaj ovulation muag hauv khw muag tshuaj;
• Ntawm qhov tod tes, LH kev soj ntsuam tsis muaj kev txaus siab rau kev kuaj mob menopause (HAS 2005) (1).

Hauv tib neeg

• nyob rau hauv lub xub ntiag ntawm cov cim qhia ntawm precocious los yog lig puberty;
• Nyob rau hauv cov ntaub ntawv ntawm kev xeeb tub tsis yooj yim: ib tug hormonal kev ntsuam xyuas kuj systematically nqa tawm nyob rau hauv cov txiv neej. Nws suav nrog qhov tshwj xeeb ntawm LH kev xeem.

LH raug soj ntsuam los ntawm kev kuaj ntshav yooj yim. Hauv cov poj niam, nws tau ua nyob rau hnub thib 2, 3 lossis 4 ntawm lub voj voog nyob rau hauv lub chaw soj nstuam, tib lub sij hawm raws li FSH thiab estradiol kev soj ntsuam. Hauv qhov xwm txheej ntawm amenorrhea (tsis muaj lub sijhawm), tus qauv tuaj yeem coj mus rau txhua lub sijhawm.

Nyob rau hauv cov ntsiab lus ntawm kev kuaj mob lig los yog precocious puberty nyob rau hauv ib tug hluas nkauj los yog tub hluas, cov zis ntau npaum yuav nyiam. Cov gonadotropins FSH thiab LH raug tso tawm hauv lub cev pulsatile thaum lub sijhawm puberty thiab raug tshem tawm hauv cov zis. Kev noj tshuaj tso zis yog li ntawd ua rau nws muaj peev xwm txheeb xyuas cov qib secretion zoo dua li kev noj cov kua dej raws sij hawm.

Hauv menyuam yaus

Cov qib siab ntawm FSH thiab LH tuaj yeem yog ib qho cim ntawm kev puberty precocious.

Hauv poj niam

Schematically, qib LH siab ua rau lub zes qe menyuam tsis txaus (ib qho teeb meem ntawm zes qe menyuam lawv tus kheej ua rau gonadal insufficiency) uas tej zaum yuav yog vim:

• congenital anomaly ntawm zes qe menyuam;
• chromosomal abnormality (Turner syndrome tshwj xeeb);
• kev kho mob lossis kev phais uas cuam tshuam rau zes qe menyuam ua haujlwm (chemotherapy, radiotherapy);
• polycystic zes qe menyuam syndrome (PCOS):
• thyroid kab mob los yog kab mob adrenal;
• qog ntawm zes qe menyuam.

Hloov pauv, qib LH qis ua rau muaj kev cuam tshuam ntawm zes qe menyuam theem nrab ntawm lub hauv paus loj (hypothalamus thiab pituitary) ua rau tsis muaj peev xwm ntawm gonadal stimulation. Ib qho ntawm feem ntau ua rau yog prolactin pituitary adenoma.

Hauv tib neeg

Ib qho txawv txav siab ntawm LH coj qhov kev kuaj mob mus rau thawj qhov kev ua tsis tiav uas yuav yog vim:

• chromosomal abnormality;
• tsis muaj kev loj hlob ntawm cov noob qes (testicular agenesis);
• testicular raug mob;
• tus kab mob;
• kev kho mob (radiotherapy, chemotherapy);
• qog nqaij hlav qog;
• tus kab mob autoimmune.

Qib LH qis rov qab mus rau qhov tsis zoo ntawm lub hauv paus chiv keeb, nyob rau hauv pituitary thiab hypothalamus (pituitary qog, piv txwv li) ua rau cov qog ntshav tsis ua haujlwm.