Cov kws tshawb fawb los ntawm Lodz University of Technology tau tsim ib qho tshiab hydrogel hnav khaub ncaws rau kev kho mob ntshav qab zib qhov txhab. Kev hnav khaub ncaws muab ib qho tetrapeptide rau lub qhov txhab uas tuaj yeem kho thiab tsim cov hlab ntsha tshiab hauv nws.
Raws li cov kws tshawb fawb, kev siv cov hnav khaub ncaws zoo li no tuaj yeem txo tus naj npawb ntawm amputations.
Kev kho mob ntawm qhov txhab mob ntshav qab zib yog tam sim no muaj teeb meem loj dua hauv tebchaws Poland thiab hauv ntiaj teb tshaj li kev kho mob ntawm lwm hom qhov txhab. Tus nqi ntawm cov kev kho mob zoo li no nrog rau kev sib raug zoo ntawm cov mob ntshav qab zib yog qhov loj heev - vim li no hauv tebchaws Poland tshaj 10 qhov kev kho mob tau ua txhua xyoo. limb amputation. Vim qhov tshwj xeeb ntawm cov qhov txhab no, tsis muaj biomaterials tau tsim nyob rau hauv lub ntiaj teb no uas yuav ua rau kom muaj txiaj ntsig zoo ntawm lawv txoj kev kho.
Pab neeg ntawm prof. Janusz Rosiak los ntawm Interdepartmental Institute of Radiation Technology ntawm Lodz University of Technology tau tsim cov thev naus laus zis rau kev tsim cov hydrogel dressings enriched nrog tetrapeptide, uas ua rau angiogenesis, piv txwv li rov kho thiab tsim cov hlab ntsha tshiab hauv qhov txhab. Kev kuaj cellular ntawm cov khoom siv biomaterial no muab cov txiaj ntsig zoo.
Kev hnav khaub ncaws yog tsim los ntawm kev hnav khaub ncaws hydrogel tsim los ntawm cov kws tshawb fawb los ntawm Łódź, uas - raws li lawv cov thev naus laus zis - tau tsim tawm thoob plaws ntiaj teb rau ntau tshaj 20 xyoo. Nws muaj cov khoom ntawm kev hnav khaub ncaws zoo tshaj plaws, thiab ua tsaug rau nws, cov txiaj ntsig zoo tau ua tiav hauv kev kho mob ntawm qhov txhab kub hnyiab, bedsores thiab qhov txhab uas nyuaj rau kho, xws li trophic ulcers.
Hydrogel hnav khaub ncaws siv ncaj qha rau lub qhov txhab, incl. muab cov pa oxygen nkag mus rau hauv lub qhov txhab, ua ib qho thaiv kev tiv thaiv kab mob sab nraud, absorbs exudates, muab qhov chaw noo noo, txo qhov mob, tshem tawm cov ntaub so ntswg necrotic ntawm lub qhov txhab thaum tshem tawm ntawm lub qhov txhab. Nyob rau tib lub sijhawm, nws ua rau nws muaj peev xwm muab cov tshuaj yeeb tshuaj (qhov no yog tetrapeptide) ntawm tus nqi tas mus li, tsis tas yuav tsum muaj tus kws kho mob cuam tshuam.
Nws zoo nkaus li tias cov kev daws teeb meem peb tau tsim tuaj yeem muaj txiaj ntsig zoo hauv kev kho mob ntshav qab zib qhov txhab. Tus nqi tsim khoom ntawm kev hnav khaub ncaws yog tsawg heev, thiab nws cov khoom tuaj yeem ua tau zoo yam tsis muaj kev nqis peev loj - hais rau PAP, tus tsim ntawm kev hnav khaub ncaws, Prof. Janusz Rosiak.
Kev hnav khaub ncaws rau kev kho mob ntshav qab zib qhov txhab tam sim no xav tau kev pib ua ntej thiab kev sim tshuaj, uas - raws li Prof. Rosiak - tsis yog nyiaj txiag los ntawm lub xeev. Tias yog vim li cas peb txaus siab koom tes nrog cov tuam txhab xav tau kev tsim cov khaub ncaws zoo li no - nws hais ntxiv.
Thaum kho nrog classic hydrogel hnav khaub ncaws ua raws li Rosiak txoj kev, nws tau pom tias nws muaj txiaj ntsig zoo hauv kev kho mob ntawm cov kab mob hu ua mob ntshav qab zib ko taw, tab sis qhov tshwm sim ntawm kev kho hom mob no nrog kev siv cov hnav khaub ncaws zoo li no. txog 50 feem pua. - Ntau npaum li rau lwm hom kev hnav khaub ncaws paub thiab siv hauv ntiaj teb.
Qhov no muaj feem xyuam rau qhov tshwj xeeb ntawm cov mob ntshav qab zib mellitus, vim lawv txawv ntawm lwm tus, necrosis ntawm cov ntaub so ntswg vim kev puas tsuaj thiab kev puas tsuaj ntawm cov hlab ntsha. Nws kuj tseem cuam tshuam nrog kev puas tsuaj ntawm cov paj hlwb thiab maj mam tuag ntawm cov ntaub so ntswg ncig lub qhov txhab.
Kev sim kho hom mob no, ua haujlwm hauv tebchaws Poland thiab thoob plaws ntiaj teb, nqis los txheeb xyuas hom kab mob thiab siv tshuaj tua kab mob lossis lwm yam khoom siv uas tuaj yeem txhim kho qhov huv ntawm lub qhov txhab. Thaum tos lub qhov txhab kom zoo, yam uas tuaj yeem ua rau angiogenesis, piv txwv li kev kho thiab tsim cov hlab ntsha tshiab hauv lub qhov txhab, tuaj yeem xa mus rau nws. Rau lub hom phiaj no, kev siv ntau yam tshuaj, thiaj li hu ua kev loj hlob yam.
Prof. Rosiak piav qhia tias nyob rau hauv lawv cov kev tshawb fawb, cov kws tshawb fawb los ntawm Łódź ntsib cov lus ceeb toom hauv cov ntaub ntawv ntawm kev siv tetrapeptide yooj yim rau induce angiogenesis los ntawm kev xa mus rau thaj chaw kho mob ntawm lub cev. Nws yog ib qho chaw tsim nyob rau hauv tib neeg lub cev, nrog rau ib nrab-lub neej luv luv ntawm 5 feeb, yog li nws cov concentration hauv ib txwm ua haujlwm ntawm lub cev yog tsawg heev. Cov tetrapeptide no tau sau npe ua tshuaj thiab pom zoo los ntawm US Food and Drug Administration (FDA).
Txawm li cas los xij, nws cov kev tswj hwm rau cov ntaub so ntswg nyob ib puag ncig lub qhov txhab tau ua tiav los ntawm kev txhaj tshuaj, uas ua rau nws tsis tuaj yeem tswj hwm thaj tsam ntawm kev ua haujlwm thiab ua rau muaj kev cuam tshuam zoo - nrawm mus txog qhov siab thiab qhov sib npaug sai sai, uas rhuav tshem nws cov txiaj ntsig kho. Peb qhov qub, ntawm qhov ntsuas thoob ntiaj teb, lub tswv yim npau taws los sim ua ke hydrogel hnav khaub ncaws nrog tetrapeptide - piav qhia tus kws tshawb fawb.
Cov cuab yeej ntawm kev tsim cov hnav khaub ncaws hydrogel tsim los ntawm Łódź cov kws tshawb fawb muaj nyob rau hauv kev tsim kom muaj kev sib xyaw ntawm cov khoom xyaw hnav khaub ncaws hauv dej (dej suav txog ntau dua 90% ntawm nws cov muaj pes tsawg leeg), thiab tom qab ntawd tom qab muab tso rau hauv lub pob thiab kaw nws, ua kom tsis muaj menyuam nrog cov khoom siv. electron nqaj. Yog li ntawd, ib lub sterile hydrogel thaj yog tsim uas yog siv los hnav khaub ncaws.
Qhov teeb meem kev tshawb fawb yog seb cov tshuaj nquag yuav tsis raug puas tsuaj thaum lub sij hawm ua kom tsis muaj menyuam, vim hais tias tetrapeptide nyob rau hauv cov tshuaj aqueous nyob rau hauv lub hwj chim ntawm electron beam raug puas lawm tag nrho ntawm electron koob tshuaj uas tseem tsis tau xyuas kom meej sterility ntawm cov khoom. Txawm li cas los xij, peb tau daws qhov teeb meem no - ntxiv prof. Rosiak.
Cov kev daws teeb meem raug xa mus rau kev tiv thaiv ntawm Patent Office. Ua tsaug rau kev txhawb nqa nyiaj txiag ntawm National Center for Research thiab Development, cov kws tshawb fawb los ntawm Lodz tau tshawb fawb txog kinetics ntawm kev tso tawm tetrapeptide rau hauv lub qhov txhab, nws cov kav ntev hauv kev hnav khaub ncaws (nws tuaj yeem siv txawm tias ib xyoos tom qab nws tsim tawm) thiab kev cuam tshuam nrog cov cell.
Nyob rau theem molecular, peb tau lees paub qhov kev qhia ntawm cov noob muaj lub luag haujlwm rau angiogenesis, thiab ntawm qib cellular, ib qho tseem ceeb acceleration ntawm proliferation ntawm endothelial hlwb. Peb kuj tau qhia txog kev vam khom ntawm cov txiaj ntsig tau los ntawm cov concentration ntawm tetrapeptide thiab peb txiav txim siab qhov kev pom zoo - tus xibfwb tau sau tseg.
Cov kws tshawb fawb tshaj tawm tias yog lawv tsis pom cov peev nyiaj los tshawb fawb ntxiv txog kev hnav khaub ncaws, lawv tsis txiav txim siab tias lawv yuav ua kom paub txog lawv lub tswv yim rau pej xeem. Qhov teeb meem ntawm kev kho tus mob ntshav qab zib ko taw cuam tshuam rau tib neeg thoob plaws ntiaj teb thiab peb tsis tas yuav tsum tau nyiaj rau nws - ntseeg prof. Rosiak. (PAP)