Qhov concentration ntawm uric acid tuaj yeem txiav txim siab hauv cov ntshav lossis hauv cov zis. Ua kom dhau, nws feem ntau yog cov tsos mob ntawm gout, haus cawv ntau dhau lossis lub raum tsis ua haujlwm.

Uric acid yog a pov tseg ntawm lub cev. Tshwj xeeb, nws yog qhov kawg khoom ntawm lubtshem tawm molecules hu ua nucleic acids thiab purines.

Feem ntau, feem ntau ntawm cov uric acid nyob rau hauv tib neeg lub cev dissolves nyob rau hauv cov ntshav thiab nkag mus rau lub raum kom tshem tawm nyob rau hauv cov zis. Tab sis qee zaum, lub cev tsim cov uric acid ntau dhau los yog tsis tshem nws txaus. Cov mob no tuaj yeem ua rau muaj ntau yam teeb meem.

Uric acid yog qhov kawg khoom ntawm degradation ntawm slurry, nws tus nqi sib txawv nyob ntawm seb cov ntsiab lus purine hauv lub cev. Thiab nws hloov tawm tias purines muaj nyob rau hauv tshwj xeeb hauv cov khoom noj. 

Qee cov khoom noj uas muaj purines kom zam tau yog:

• anchovies, herring, mackerel, sardines, cws, thiab lwm yam;
• daim siab, plawv, hlwb, raum, qab zib, thiab lwm yam;
• peas, taum qhuav, thiab lwm yam.

Kev haus cawv, thiab tshwj xeeb npias, tsis pom zoo thaum koj xav txo koj cov uric acid.

Ntawm qhov tsis sib xws, ntawm cov zaub mov tso cai qis hauv purine, peb tuaj yeem hais txog:

• tshuaj yej, kas fes, dej qab zib;
• txiv hmab txiv ntoo thiab zaub;
• qe;
• qhob cij thiab cereals;
• cheese thiab ntau yam khoom noj siv mis

Vim li cas thiaj kuaj uric acid?

Tus kws kho mob tau sau ntawv mus kuaj ntshav (hu ua uricemia) thiab / lossis kuaj uric acid rau:

• kuaj mob gout;
• ntsuas seb lub raum ua haujlwm zoo npaum li cas;
• nws tseem tuaj yeem thov thaum cev xeeb tub;
• los yog hauv cov neeg rog rog.

Nco ntsoov tias kev tsom xam ntawm qhov concentration ntawm uric acid nyob rau hauv cov zis kuj yuav ua rau nws muaj peev xwm nkag siab zoo dua lub hauv paus chiv keeb ntawm qib siab ntawm uric acid nyob rau hauv cov ntshav.

Hauv cov ntshav, tus nqi ib txwm muaj ntawm uric acid nyob nruab nrab ntawm 35 thiab 70 mg / L.

Qhov siab dua ntawm uric acid hauv cov ntshav yog hu ua hyperuricemia thiab tuaj yeem tshwm sim los ntawm kev tsim tawm ntau dhau ntawm uric acid hauv lub cev lossis los ntawm kev txo qis hauv kev tshem tawm ntawm lub raum. Yog li, qib siab ntawm uric acid hauv cov ntshav tuaj yeem yog ib qho cim ntawm:

• gout (qhov no yog qhov laj thawj tseem ceeb ntawm kev nce qib ntawm uric acid hauv cov ntshav);
• ntau dhau ntawm degradation ntawm cov proteins ntawm cov kab mob uas tshwm sim, piv txwv li, thaum siv tshuaj kho mob, leukemia los yog lymphoma;
• kev quav cawv;
• kev tawm dag zog lub cev ntau dhau;
• lub xub ntiag ntawm lub raum pob zeb;
• poob ceeb thawj sai;
• ntshav qab zib;
• noj zaub mov nplua nuj nyob rau hauv purine;
• preeclampsia thaum cev xeeb tub;
• los yog raum tsis ua hauj lwm.

Ntawm qhov tsis sib xws, nws muaj peev xwm hais tias cov ntshav uric acid qib qis dua li qub, tab sis qhov no yog qhov tsis tshua muaj tshwm sim tshaj qhov xwm txheej uas nws xaus siab dua.

Yog li, cov qib uric acid hauv qab cov nqi ib txwm muaj feem xyuam rau:

• noj tsawg-purine;
• Wilson tus kab mob (ib hom kab mob uas tooj liab tsim hauv lub cev);
• raum (xws li Fanconi syndrome) los yog daim siab puas;
• los yog tseem raug rau cov tshuaj lom neeg sib xyaw ua ke ( txhuas ).

Hauv cov zis, tus nqi ib txwm muaj ntawm uric acid nyob nruab nrab ntawm 250 thiab 750 mg / 24 teev.

Nco ntsoov tias qhov txiaj ntsig ib txwm yuav txawv me ntsis nyob ntawm lub chaw soj ntsuam ua qhov ntsuas.

Kev cuam tshuam rau 5 mus rau 15% ntawm cov pejxeem, nws yog ib qho kev txawv txav ntawm biochemical abnormality, uas tshwm sim los ntawm overproduction ntawm uric acid thiab / los yog txo lub raum tshem tawm. Nws feem ntau txhim kho tsis mob thiab yog li tsis tas kuaj pom tam sim ntawd.

Cov qib uric acid siab tuaj yeem piav qhia los ntawm:

Idiopathic lossis thawj hyperuricemia

Lawv sawv cev rau feem coob ntawm cov neeg mob. Cov kab mob tshwm sim muaj nyob hauv 30% ntawm cov neeg mob, tab sis lawv feem ntau cuam tshuam nrog kev rog, noj ntau dhau, ntshav siab, haus dej cawv, ntshav qab zib thiab hypertriglyceridemia.

Tsis tshua muaj enzyme abnormalities

Lawv pom tshwj xeeb hauv kab mob Von Gierke thiab Lesch-Nyhan kab mob. Cov enzymatic txawv txav no muaj qhov tshwj xeeb ntawm kev ua rau gout tawm tsam ntxov heev, piv txwv li hauv thawj 20 xyoo ntawm lub neej.

Hyperuricemia thib ob rau kab mob lossis kev kho tshuaj.

Cov hyperuricemia tuaj yeem yog vim:

- tsis muaj kev tshem tawm ntawm uric acid. Qhov no yog qhov tshwm sim rau lub raum tsis ua haujlwm, tab sis kuj yog vim muaj qee yam tshuaj (diuretics, tab sis kuj yog laxatives thiab qee cov tshuaj tiv thaiv kab mob).

- nce nyob rau hauv degradation ntawm nucleic acids. Peb pom qhov no hauv cov kab mob ntshav (leukemia, hemopathies, hemolytic anemia, ntau psoriasis), thiab qhov tshwm sim ntawm qee yam kev kho mob qog noj ntshav.

Qhov tshwm sim ntawm hyperuricemia

Hyperuricemia tuaj yeem ua rau ob hom teeb meem:

• Gout lub luag hauj lwm rau inflammatory-hom pob qij txha.

Thaum cov microcrystals ntawm uric acid yaj nyob rau hauv cov ntshav yog nyob rau hauv ib tug siab concentration thiab lub zos tej yam kev mob zoo (tshwj xeeb tshaj yog ib tug txaus acidity ntawm nruab nrab), lawv precipitate thiab ua rau lub zos o. Qhov no zoo dua cuam tshuam rau kev sib koom tes ntawm tus ntiv taw loj. Tsuas yog 1 ntawm 10 tus neeg uas muaj uric acid ntau dhau hauv lawv cov ntshav yuav kis tau tus kab mob gout, yog li koj xav tau kev tiv thaiv ntxiv kom tau txais nws.

• Urinary lithiasis.

Lawv yog vim muaj ib los yog ntau lub pob zeb nyob rau hauv lub urinary ib ntsuj av thiab muaj lub luag hauj lwm rau lub raum colic. Urolithiasis yog ib yam kab mob ntau heev txij li 1 txog 2% ntawm cov pej xeem raug cuam tshuam hauv Fabkis.

Kev tsom xam ntawm qib ntawm ib qho kua qaub tuaj yeem ua tiav hauv cov ntshav thiab / lossis hauv cov zis:

• kev kuaj ntshav muaj cov qauv ntawm cov ntshav venous, feem ntau nyob rau hauv lub crease ntawm lub luj tshib;
• theem ntawm uric acid nyob rau hauv cov zis yog ntsuas tshaj 24 teev: ua li no, nws yog txaus tso zis nyob rau hauv ib lub thawv uas muab rau lub hom phiaj no thiab muab los ntawm cov kws kho mob rau ib hnub thiab ib hmo.

Nco ntsoov tias nws raug nquahu kom tsis txhob noj lossis haus ib yam dab tsi thaum lub sijhawm ua ntej qhov kev xeem.

Muaj ntau yam uas tuaj yeem cuam tshuam rau qib uric acid hauv cov ntshav lossis hauv cov zis. Cov no suav nrog:

• khoom noj (tsis zoo los yog siab hauv purines);
• tshuaj (kos npe rau gout, aspirin, lossis txawm tias diuretics);
• hnub nyoog, cov menyuam yaus uas muaj nqi qis dua;
• poj niam txiv neej, nrog cov poj niam feem ntau muaj qis dua txiv neej;
• qhov hnyav, cov neeg rog rog muaj tus nqi siab dua.

Kev kho tshuaj yog tias hyperuremia yog cov tsos mob raws li hauv qab no: 

• Nucleic acid synthesis reducers, xws li allopurinol. Koj yuav tsum tau ceev faj heev vim tias muaj ntau yam kev cuam tshuam nrog lwm yam tshuaj.
• Cov tshuaj uas inhibit lub raum uric acid reabsorption, xws li benzbromarone.
• Kev kho enzymatic uas feem ntau ua rau muaj teeb meem tsis haum.

Txawm li cas los xij, nws yog tus kws kho mob uas yuav tsum txiav txim siab seb puas yuav tsum tau ua raws li kev kho mob, thiab qhov twg yog qhov tsim nyog tshaj.