Cov ntaub ntawv pov thawj ntawm kev hloov pauv hauv cov teeb meem dawb uas nyob ib puag ncig cov neurons, kev loj hlob multifocal leukoencephalopathy yog cov kab mob neurological uas ib txhij cuam tshuam rau ntau thaj tsam ntawm lub hlwb thiab nce zuj zus. Nws ua rau muaj ntau yam. 

Neurons (cov paj hlwb hauv lub hlwb) txuas ntxiv los ntawm cov paj hlwb, hu ua axons, uas yuav txuas nrog lwm tus hauv lub hlwb los ntawm synapses (kawg ntawm axon). Cov paj hlwb no nyob ib puag ncig los ntawm cov ntaub qhwv (myelin) uas cais lawv ntawm ib leeg thiab yog ib feem ntawm cov teeb meem dawb ntawm lub hlwb.

Progressive multifocal leukoencephalopathy (PML) ua tim khawv rau kev hloov pauv hauv ntau qhov chaw ntawm lub hlwb ntawm cov ntaub qhwv no uas nyob ib puag ncig cov axons, ua rau luv luv ntawm lawv. Cov luv luv circuits no yog nyob rau hauv keeb kwm ntawm lub dysfunctions ntawm lub paj hlwb nyob rau hauv relation mus rau lub mobilization ntawm cov nqaij ntshiv, ntawm lub hlwb kev ua si (xav los yog kev txawj ntse) thiab cov hlab ntsha fibers ntawm rhiab heev. Li no qhov tshwm sim ntawm tuag tes tuag taw, cuam tshuam ntawm kev xav thiab rhiab heev.

Cov kab mob degenerative neurological no feem ntau yog kev loj hlob, evolving hauv spurts los yog qeeb heev thiab ib txhij cuam tshuam rau ntau qhov chaw ntawm lub hlwb (multifocal). Nws ua rau muaj ntau yam thiab nws cov tsos mob nyob ntawm qhov chaw cuam tshuam.

Qhov ua rau muaj kev vam meej multifocal leukoencephalopathy (PML) muaj ntau thiab ntau yam hauv cov xwm txheej:

Keeb xeeb los yog caj ces

Qee lub sij hawm pib thaum ntxov xws li qee yam mob lossis kab mob xws li Cadasil's kab mob txuas nrog kev hloov pauv caj ces, Childhood Ataxia syndrome ntawm keeb kwm ntawm kab noj hniav hauv cov teeb meem dawb ntawm lub hlwb los ntawm kev puas tsuaj ntawm myelin, ntau yam sclerosis (MS) uas tshwm sim ntawm lub hauv paus keeb kwm thiab qee zaum ua rau kab noj hniav (cavitary daim ntawv ntawm MS), los yog cov kab mob degenerative ntawm lub hlwb xws li fragile X syndrome lossis kab mob mitochondrial.

Vascular keeb kwm

Nws yog vascular dementia tshwm sim los ntawm kev puas tsuaj rau cov hlab ntsha me ntawm lub hlwb (microangiopathy), muaj feem xyuam rau hnub nyoog, laus thiab tsis muaj ntshav siab lossis ntshav qab zib.

Ntawm cov tshuaj lom neeg 

Los ntawm kev noj qee yam tshuaj xws li methotrexate siv rau hauv kev kho mob qog noj ntshav lossis kab mob autoimmune (rheumatoid mob caj dab lossis RA, thiab lwm yam), nitric oxide lom (ua kom sov nrog cov pa tsis zoo) lossis nqus cov tshuaj yeeb dej caw (kev siv yeeb tshuaj). Kev kho hluav taws xob kuj tuaj yeem hloov cov teeb meem dawb hauv lub hlwb.

Los ntawm degenerative keeb kwm

Nws tau txuas nrog cov txheej txheem inflammatory uas cuam tshuam rau lub paj hlwb xws li MS, leucoaraiosis, lossis Alzheimer's kab mob, qee zaum ntawm keeb kwm keeb kwm tab sis tsis tas li, nrog rau cov kab mob tom kawg ntawm kev sib sau ntawm cov deposits uas yuav cuam tshuam kev xa mus rau cov paj hlwb (amyloid deposits thiab neurofibrillary degeneration cuam tshuam nrog rau cov kab mob inflammatory muaj cov proteins hauv lub hlwb, beta-amyloid peptide thiab tau protein).

Mob kis tuaj

Tsis tshua muaj kab mob xws li papillomavirus (JC virus) lossis AIDS (2 mus rau 4% ntawm HIV + neeg).

Cov tsos mob ntawm kev nce qib multifocal leukoencephalopathy (PML) txawv nyob ntawm thaj chaw cuam tshuam thiab ua rau cov txheej txheem degenerative hauv lub hlwb:

• tsis muaj zog, nyuaj hais lus lossis xav thaum pib ntawm tus kab mob;
• txhob txwm tremor (cerebellar syndrome) thiab gait cuam tshuam nyob rau hauv fragile X syndrome los yog mitochondrial kab mob, kev tsis txaus siab ntawm kev sib koom tes, cov tsos mob qhia thaum ntxov ntawm cov hereditary los yog genetic pathologies thiab nce zuj zus thiab inevitably ...;
• kev puas siab puas ntsws thaum lub sij hawm degeneration ntawm vascular keeb kwm, feem ntau tshwm sim tom qab nyob rau hauv cov neeg laus nrog mus ob peb vas, kev paub tsis meej (temporo-spatial disorientation, nco tsis meej), qee zaum delusions thiab tsis meej pem;
• impaired rhiab heev thiab lub cev muaj zog kev txawj ntse nyob rau hauv degenerations ntawm toxic keeb kwm;
• kev txawj ntse poob rau hauv lub hlwb degeneration xws li Alzheimer's kab mob nrog impaired nco, kev taw qhia, kev saib xyuas, kev daws teeb meem, kev npaj thiab koom haum, kev xav;
• txoj kev pheej hmoo ntawm cerebrovascular kev huam yuaj (stroke) yog nce nyob rau hauv kev loj hlob multifocal leukoencephalopathy;
• migraines thiab qaug dab peg.

Cov tsos mob ntawm tus kab mob no twb qhia txog cov kab mob no, tab sis nws yuav yog lub paj hlwb imaging xws li Magnetic Resonance Imaging (MRI) uas yuav ua rau nws muaj peev xwm nrhiav tau cov kab mob uas qhia txog cov teeb meem dawb ntawm lub hlwb.

Kev kuaj pom tus kab mob JC los ntawm lumbar puncture yog qee zaum qhia thaum muaj kev xav tias muaj kev vam meej multifocal leukoencephalopathy ntawm viral keeb kwm.

Kev kuaj mob AIDS feem ntau yog ua tiav thiab yog tias tsis yog, nws yuav tsum tau tshawb fawb.

Kev kho mob ntawm cov kab mob multifocal leukoencephalopathy yog qhov ua rau:

• tshawb nrhiav tshuaj lom (tshuaj, tshuaj yeeb dawb, thiab lwm yam) thiab tshem tawm lawv; 
• Kev lees paub ntawm kev kuaj mob cerebral degeneration rau Alzheimer's kab mob, MS, leukoaraiosis, dementia ntawm vascular keeb kwm.

Cov kab mob ntawm cov teeb meem dawb yuav nyob twj ywm irreversible thiab kev puas siab puas ntsws kev txhawb nqa thiab kev txawj ntse stimulation yuav qeeb qhov kev loj hlob ntawm tus kab mob no uas tej zaum yuav evolved ntau xyoo.