Cov txheej txheem kev laus ntawm qib cellular tuaj yeem tsis tsuas yog nres tab sis kuj thim rov qab. Cov kws tshawb fawb hauv Tebchaws Meskas tau tswj hwm coj cov leeg ntawm tus nas muaj 6 xyoo mus rau lub xeev cov leeg nqaij ntawm 60-hli nas, uas yog sib npaug rau 40 xyoo ntawm kev rov ua kom lub cev ntawm tus menyuam muaj hnub nyoog XNUMX xyoos. Nyob rau hauv lem, cov kws tshawb fawb los ntawm lub teb chaws Yelemees rejuvenated lub hlwb los ntawm kev thaiv tsuas yog ib tug signaling molecule.
Pab pawg kws tshawb fawb los ntawm Harvard Medical School coj los ntawm prof. Cov noob caj noob ces los ntawm David Sinclair, ua qhov kev tshawb pom no, raws li nws tau ua, nyob rau lub sijhawm ntawm kev tshawb fawb rau hauv intracellular signaling. Nws tshwm sim los ntawm kev sib cuam tshuam ntawm signaling molecules. Lawv feem ntau yog cov proteins uas, nrog kev pab ntawm cov tshuaj sib txuas hauv lawv cov qauv, hloov cov ntaub ntawv los ntawm ib cheeb tsam ntawm tes mus rau lwm qhov.
Raws li nws muab tawm thaum lub sij hawm kev tshawb fawb, kev cuam tshuam ntawm kev sib txuas lus ntawm lub cell nucleus thiab mitochondria ua rau kom ceev aging ntawm hlwb. Txawm li cas los xij, cov txheej txheem no tuaj yeem thim rov qab - hauv kev tshawb fawb hauv tus qauv nas, nws tau pom tias kev sib txuas lus intracellular rejuvenates cov ntaub so ntswg thiab ua rau nws saib thiab ua haujlwm zoo ib yam li cov nas me.
Cov txheej txheem kev laus hauv lub xovtooj ntawm tes, pom los ntawm peb pab pawg, yog qhov nco txog kev sib yuav - thaum nws tseem hluas, nws sib txuas lus tsis muaj teeb meem, tab sis dhau sij hawm, thaum nws nyob ze rau ntau xyoo, kev sib txuas lus maj mam tso tseg. Restoreing kev sib txuas lus, ntawm qhov tod tes, daws txhua yam teeb meem - hais tias prof. Sinclair.
Mitochondria yog ib qho tseem ceeb tshaj plaws ntawm cov cell organelles, xws li qhov loj ntawm 2 mus rau 8 microns. Lawv yog qhov chaw uas, raws li cov txheej txheem ntawm kev ua pa ntawm tes, feem ntau ntawm adenosine triphosphate (ATP) yog tsim nyob rau hauv lub cell, uas yog nws lub zog. Mitochondria tseem koom nrog hauv xov tooj ntawm tes taw qhia, kev loj hlob thiab apoptosis, thiab kev tswj hwm tag nrho lub neej ntawm tes.
Kev tshawb fawb los ntawm pab neeg ntawm prof. Sinclair qhov kev tsom mus rau ib pawg ntawm cov noob hu ua sirtuins. Cov no yog cov noob uas code rau Sir2 proteins. Lawv koom nrog ntau cov txheej txheem txuas ntxiv hauv cov hlwb, xws li kev hloov pauv tom qab kev hloov pauv ntawm cov protein, ua kom tsis muaj cov noob hloov pauv, ua kom DNA kho cov txheej txheem thiab kev tswj hwm cov txheej txheem metabolic. Ib qho ntawm cov noob caj noob ces, SIRT1, tej zaum yuav yog, raws li kev tshawb fawb yav dhau los, qhib los ntawm resveratol - cov tshuaj lom neeg pom, ntawm lwm tus, hauv txiv hmab txiv ntoo, liab caw thiab qee yam txiv ntoo.
Cov genome tuaj yeem pab tau
Cov kws tshawb fawb tau pom cov tshuaj uas lub xov tooj ntawm tes tuaj yeem hloov mus rau hauv NAD + uas rov qab sib txuas lus ntawm nucleus thiab mitochondria los ntawm kev ua haujlwm zoo ntawm SIRT1. Kev tswj xyuas nrawm ntawm qhov sib xyaw no tso cai rau koj kom thim rov qab cov txheej txheem kev laus tag nrho; qeeb, piv txwv li tom qab lub sijhawm ntev, nws qeeb qeeb thiab txo nws cov teebmeem.
Hauv chav kawm ntawm kev sim, cov kws tshawb fawb tau siv cov leeg nqaij ntawm tus nas uas muaj hnub nyoog ob xyoos. Nws cov hlwb tau muab cov tshuaj sib xyaw ua ke uas tau hloov pauv mus rau NAD +, thiab kuaj xyuas qhov ntsuas ntawm insulin tsis kam, cov leeg nqaij so thiab mob. Lawv qhia txog lub hnub nyoog ntawm cov leeg nqaij. Raws li nws tau muab tawm, tom qab tsim NAD + ntxiv, cov leeg nqaij ntawm tus nas muaj 2 xyoos tsis txawv ntawm ib qho ntawm tus nas 6 hli. Nws yuav zoo li rejuvenating cov leeg ntawm ib tug 60-xyoo-laus mus rau lub xeev ntawm ib tug 20-xyoo-laus.
Los ntawm txoj kev, lub luag haujlwm tseem ceeb ua los ntawm HIF-1 tau los txog. Qhov teeb meem no decomposes sai heev nyob rau hauv ib txwm oxygen concentration tej yam kev mob. Thaum muaj tsawg ntawm nws, nws accumulates nyob rau hauv cov ntaub so ntswg. Qhov no tshwm sim raws li lub hnub nyoog hlwb, tab sis kuj nyob rau hauv qee hom mob qog noj ntshav. Qhov no yuav piav qhia tias vim li cas qhov kev pheej hmoo ntawm mob qog noj ntshav nce ntxiv nrog lub hnub nyoog thiab tib lub sijhawm qhia tau hais tias lub cev ntawm kev tsim mob qog noj ntshav zoo ib yam li kev laus. Ua tsaug rau kev tshawb fawb ntxiv, nws txoj kev pheej hmoo yuav tsum raug txo, hais tias Dr. Ana Gomes los ntawm pab pawg ntawm Prof. Sinclair.
Tam sim no, kev tshawb fawb tsis yog ntawm cov ntaub so ntswg, tab sis ntawm cov nas nyob. Cov kws tshawb fawb los ntawm Tsev Kawm Ntawv Kho Mob Harvard xav pom tias lawv lub neej yuav nyob ntev npaum li cas tom qab siv txoj hauv kev tshiab ntawm kev sib txuas lus hauv lub cev.
Koj puas xav ncua kev laus ntawm daim tawv nqaij? Sim ib qho ntxiv nrog coenzyme Q10, cream-gel rau thawj cov cim ntawm kev laus lossis ncav cuag lub teeb hiav txwv buckthorn cream Sylveco rau thawj cov cim ntawm kev laus los ntawm Medonet Market muab.
Ib qho molecule thaiv cov neurons
Nyob rau hauv lem, ib pab neeg ntawm cov kws tshawb fawb los ntawm German chaw tshawb fawb mob cancer - Deutsches Krebsforschungszentrum (DKFZ) coj los ntawm Dr. Any Martin-Villalba, tshawb nrhiav lwm qhov tseem ceeb ntawm cov txheej txheem kev laus - kev poob siab, kev xav thiab kev nco. Cov teebmeem no tshwm sim los ntawm kev poob ntawm cov neurons hauv lub hlwb nrog lub hnub nyoog.
Pab neeg no tau txheeb xyuas qhov taw qhia molecule hauv lub hlwb ntawm tus nas qub hu ua Dickkopf-1 lossis Dkk-1. Thaiv nws cov kev tsim tawm los ntawm kev ntsiag to cov noob uas yog lub luag haujlwm rau nws qhov kev tsim ua rau muaj qhov nce ntawm cov neurons. Los ntawm kev thaiv Dkk-1, peb tso lub neural nres, rov pib qhov kev ua tau zoo hauv kev nco qab mus rau qib pom hauv cov tsiaj hluas, hais tias Dr. Martin-Villalba.
Neural qia hlwb muaj nyob hauv hippocampus thiab muaj lub luag haujlwm rau kev tsim cov neurons tshiab. Cov molecules tshwj xeeb nyob rau thaj tsam tam sim ntawm cov hlwb no txiav txim siab lawv lub hom phiaj: lawv tuaj yeem nyob tsis ua haujlwm, rov ua dua lawv tus kheej, lossis sib txawv ua ob hom hlwb tshwj xeeb: astrocytes lossis neurons. Lub teeb liab molecule hu ua Wnt txhawb kev tsim cov neurons tshiab, thaum Dkk-1 tshem tawm nws qhov kev ua.
Kuj xyuas: Koj puas muaj pob txuv? Koj yuav hluas dua!
Cov nas laus uas tau thaiv nrog Dkk-1 tau pom yuav luag tib qhov kev ua tau zoo hauv kev nco thiab kev paub txog kev ua haujlwm raws li cov nas hluas, vim tias lawv muaj peev xwm rov ua dua tshiab thiab tsim cov neurons tsis paub qab hau hauv lawv lub hlwb tau tsim los ntawm theem tus yam ntxwv ntawm cov tsiaj hluas. Ntawm qhov tod tes, cov nas me uas tsis muaj Dkk-1 tau pom tias muaj kev cuam tshuam qis dua rau kev loj hlob ntawm kev nyuaj siab tom qab kev nyuaj siab dua cov nas ntawm tib lub hnub nyoog, tab sis nrog Dkk-1. Qhov no txhais tau hais tias los ntawm kev txo qis ntawm Dkk-1, nws tuaj yeem tsis tsuas yog nce lub peev xwm nco, tab sis kuj tiv thaiv kev nyuaj siab.
Cov kws tshawb fawb hais tias tam sim no nws yuav tsim nyog los tsim cov kev sim tshuaj lom neeg Dkk-1 inhibitors thiab tsim cov kev tsim tshuaj uas yuav pab tau lawv siv. Cov no yuav yog cov tshuaj uas ua ntau yam - ntawm ib sab, lawv yuav tiv thaiv kev poob ntawm kev nco thiab lub peev xwm paub rau cov neeg laus, thiab ntawm qhov tod tes, lawv yuav ua raws li cov tshuaj tiv thaiv. Vim qhov tseem ceeb ntawm qhov teeb meem, tej zaum nws yuav nyob ib puag ncig 3-5 xyoo ua ntej thawj cov tshuaj tiv thaiv Dkk-1 nyob rau hauv khw.